中国检验幽门螺杆菌感染方法诊断效能的分析
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张 丽, 张建中
幽门螺杆菌;诊断方法;分析张丽,张建中.中国检验幽门螺杆菌感染方法诊断效能的分析. 世界华人消化杂志2007;15(6)649-654,张丽,张建中,通讯作者:,电话:, 传真:,收稿日期:,接受日期:,Analysisof
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张丽, 张建中, 中国疾病预防控制中心传染病预防控制所 北京市 102206
通讯作者: 张建中, 102206, 北京昌平流字5号, 中国疾病预防控制中心传染病预防控制所. helico99@sina.com
电话: 010-61739319 传真: 010-61730233
收稿日期: 2006-03-18 接受日期: 2006-06-21
Analysis of different diagnostic methods of Helicobacter pylori infection in China
Li Zhang, Jian-Zhong Zhang
Li Zhang, Jian-Zhong Zhang,National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Correspondence to:Professor Jian-Zhong Zhang, National Institute for communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, P.O.Box 5, Changping District, Beijing 102206, China. helico99@sina.com
Received:2006-03-18 Accepted:2006-06-21
AbstractAIM:To analyze the literatures about diagnostic methods for H pylori infection in China, and to evaluate the values of different diagnostic methods.
METHODS:The literatures, published from 1994 to 2005 on this topic, were collected. The sensitivity, specificity, and accuracy of 10 diagnostic methods for H pylori infection were generally analyzed.
RESULTS:A total of 56 related papers were included according to the selective standard. The sensitivity, specificity and accuracy were 78.39%, 89.13%, and 86.51% for H pylori culture test; 91.47%, 93.98%, and 91.89% for pathological examination; 95.49%, 94.76%, and 95.53% for 13C-urea breath test; 96.38%, 90.80%, and 94.34% for 14C-urea breath test; 92.04%, 87.70%, and 98.83% for anti-H pylori-IgG test (using enzyme-linked immunosorbent assay); 88.14%, 89.08%, and 88.42% for rapid urease test; 94.53%, 95.56%, and 96.65% for gastric mucosa smear; 97.57%, 89.09%, and 95.44% for polymerase chain reaction; 95.57%, 93.17%, and 94.24% for stool-antigen test; 93.06%, 86.96%, and 91.32% for anti-H pylori-IgG test in saliva, respectively.
CONCLUSION: Advantages and disadvantages co-exist in the different diagnostic methods for H pylori infection at present, and the choice should be made depending on the actual situation and demands.
Key Words: Helicobacter pylori; Diagnostic method; Evaluation; Analysis
Zhang L, Zhang JZ. Analysis of different diagnostic methods of Helicobacter pylori infection in China. Shijie Huaren Xiaohua Zazhi 2007;15(6):649-654
摘要目的:对有关幽门螺杆菌(H pylori)感染诊断方法的研究文献进行分析, 评价感染H pylori诊断方法的诊断效能.
方法: 检索1994-2005的H pylori感染诊断方法的文献资料, 对检索到的相关文献按诊断方法种类分别进行原始数据合并, 然后对10种诊断方法的灵敏度(Se)、特异度(Sp)、正确率(p)进行分析.
结果: 有56项研究符合选择标准, 综合评价结果如下, H pylori培养试验: Se为78.39%, Sp为89.13%, p为86.51%; 病理组织学切片检查: Se为91.47%, Sp为93.98%, p为91.89%;13C-尿素呼吸试验: Se为95.49%, Sp为94.76%, p为95.53%;14C-尿素呼吸试验: Se为96.38%, Sp为90.80%, p为94.34%; 血清抗H pylori-IgG的ELISA法试验: Se为92.04%, Sp为87.70%, p为98.83%; 快速尿素酶诊断: Se为88 ......
张丽, 张建中, 中国疾病预防控制中心传染病预防控制所 北京市 102206
通讯作者: 张建中, 102206, 北京昌平流字5号, 中国疾病预防控制中心传染病预防控制所. helico99@sina.com
电话: 010-61739319 传真: 010-61730233
收稿日期: 2006-03-18 接受日期: 2006-06-21
Analysis of different diagnostic methods of Helicobacter pylori infection in China
Li Zhang, Jian-Zhong Zhang
Li Zhang, Jian-Zhong Zhang,National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Correspondence to:Professor Jian-Zhong Zhang, National Institute for communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, P.O.Box 5, Changping District, Beijing 102206, China. helico99@sina.com
Received:2006-03-18 Accepted:2006-06-21
AbstractAIM:To analyze the literatures about diagnostic methods for H pylori infection in China, and to evaluate the values of different diagnostic methods.
METHODS:The literatures, published from 1994 to 2005 on this topic, were collected. The sensitivity, specificity, and accuracy of 10 diagnostic methods for H pylori infection were generally analyzed.
RESULTS:A total of 56 related papers were included according to the selective standard. The sensitivity, specificity and accuracy were 78.39%, 89.13%, and 86.51% for H pylori culture test; 91.47%, 93.98%, and 91.89% for pathological examination; 95.49%, 94.76%, and 95.53% for 13C-urea breath test; 96.38%, 90.80%, and 94.34% for 14C-urea breath test; 92.04%, 87.70%, and 98.83% for anti-H pylori-IgG test (using enzyme-linked immunosorbent assay); 88.14%, 89.08%, and 88.42% for rapid urease test; 94.53%, 95.56%, and 96.65% for gastric mucosa smear; 97.57%, 89.09%, and 95.44% for polymerase chain reaction; 95.57%, 93.17%, and 94.24% for stool-antigen test; 93.06%, 86.96%, and 91.32% for anti-H pylori-IgG test in saliva, respectively.
CONCLUSION: Advantages and disadvantages co-exist in the different diagnostic methods for H pylori infection at present, and the choice should be made depending on the actual situation and demands.
Key Words: Helicobacter pylori; Diagnostic method; Evaluation; Analysis
Zhang L, Zhang JZ. Analysis of different diagnostic methods of Helicobacter pylori infection in China. Shijie Huaren Xiaohua Zazhi 2007;15(6):649-654
摘要目的:对有关幽门螺杆菌(H pylori)感染诊断方法的研究文献进行分析, 评价感染H pylori诊断方法的诊断效能.
方法: 检索1994-2005的H pylori感染诊断方法的文献资料, 对检索到的相关文献按诊断方法种类分别进行原始数据合并, 然后对10种诊断方法的灵敏度(Se)、特异度(Sp)、正确率(p)进行分析.
结果: 有56项研究符合选择标准, 综合评价结果如下, H pylori培养试验: Se为78.39%, Sp为89.13%, p为86.51%; 病理组织学切片检查: Se为91.47%, Sp为93.98%, p为91.89%;13C-尿素呼吸试验: Se为95.49%, Sp为94.76%, p为95.53%;14C-尿素呼吸试验: Se为96.38%, Sp为90.80%, p为94.34%; 血清抗H pylori-IgG的ELISA法试验: Se为92.04%, Sp为87.70%, p为98.83%; 快速尿素酶诊断: Se为88 ......
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