缩胆囊素和胰泌素对负鼠胰管压力和胰腺血流量的影响
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石承先, Chen JWC, Toouli J
缩胆囊素;胰泌素;胰管压力;胰腺血流量;负鼠石承先,ChenJWC,ToouliJ.缩胆囊素和胰泌素对负鼠胰管压力和胰腺血流量的影响. 世界华人消化杂志2007;15(6)638-640,石承先,ChenJWC,ToouliJ,通
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石承先, 贵州省人民医院普通外科 贵州省贵阳市 550002
Chen JWC, Toouli J, 澳大利亚弗林德斯大学普通和消化外科 5042
通讯作者: 石承先, 550002, 贵州省贵阳市中山东路, 贵州省人民医院普通外科. chengxianl@yahoo.com.cn
收稿日期: 2006-10-18 接受日期: 2006-12-18
Effects of cholecystokinin and secretin on pancreatic duct pressure and pancreatic blood flow in Australian brush-tailed possums
Cheng-Xian Shi, JWC Chen, J Toouli
Cheng-Xian Shi,Department of General Surgery, Guizhou Provincial Hospital, Guiyang 550002, Guizhou Province, China
JWC Chen, J Toouli,Department of General and Digestive surgery, Flinders University, 5042, Australia
Correspondence to:Cheng-Xian Shi, Department of General Surgery, Guizhou Provincial Hospital, Guiyang 550002, China. chengxianl@yahoo.com.cn
Received:2006-10-18 Accepted:2006-12-18
Abstract
AIM:To investigate the effects of cholecystokinin (CCK) and secretin on pancreatic duct pressure (PDP) and pancreatic blood flow (PBF) in Australian brush-tailed possums.
METHODS:CCK and secretin (5 mg/kg) were intravenously injected into 6 brush-tailed possums respectively. Pancreatic duct of the possums were cannulated and PDP was measured by Maclab recording system separately. PBF was measured using laser Doppler flowmetry.
RESULTS:Five minutes after CCK and secretin injection, PDP increased from 16.2 ± 1.8 and 16.8 ± 1.7 mmHg to 18.9 ± 2.1 and 25.6 ± 1.9 mmHg, and maintained high levels (17.6 ± 2.4 mmHg and 21.5 ± 2.5 mmHg) at the 15th minute (P < 0.002 and P < 0.001); PBF increased from 0.58 ± 0.09 and 0.55 ± 0.04 mL/100 g to 0.75 ± 0.11 and 0.85 ± 0.12 mL/100 g, respectively, at the beginning after CCK and secretin injection. However, CCK and secretin made a continual PDP increase along with PBF decrease till maintaining a low level (0.51 ± 0.09 mL/100 g and 0.39 ± 0.11 mL/100 g, P < 0.001) within 15 minutes, but the influence of secretin was more significant than that of CCK (P < 0.05).
CONCLUSION: PDP can be increased by CCK and secretin injection, resulting in an increase of PBF, which may be the initial factor in the pathogenesis and development of acute biliary pancreatitis.
Key Words: Cholecystokinin; Secretin; Pancreatic duct pressure; Pancreatic blood flow; Possums
Shi CX, Chen JWC, Toouli J. Effects of cholecystokinin and secretin on pancreatic duct pressure and pancreatic blood flow in Australian brush-tailed possums. Shijie Huaren Xiaohua Zazhi 2007;15(6):638-640
摘要目的: 观察缩胆囊素和胰泌素对胰管压力及胰腺血流量的影响, 以探讨急性胆源性胰腺炎的发病机制.
方法: 6只负鼠静脉灌注缩胆囊素和胰泌素5 mg/kg, 分别胰管插管, 并连接到压力感受器上测定胰管压力, 激光多普勒测定胰腺血流量.
结果: 在注射缩胆囊素和胰泌素后5 min, 胰管压力分别由16.2±1.8 mmHg和16.8±1.7 mmHg上升到18.9±2.1 mmHg和25.6±1.9 mmHg, 在随后的5-15 min期间, 胰管压力在此水平缓慢的下降并维持在较高的水平, 分别为17.6±2.4 mmHg和21.5±2.5 mmHg (P<0.002和P<0.001); 胰腺血流量分别由0.58±0.09 mL/100 g和0.55±0.04 mL/100 g上升到0 ......
石承先, 贵州省人民医院普通外科 贵州省贵阳市 550002
Chen JWC, Toouli J, 澳大利亚弗林德斯大学普通和消化外科 5042
通讯作者: 石承先, 550002, 贵州省贵阳市中山东路, 贵州省人民医院普通外科. chengxianl@yahoo.com.cn
收稿日期: 2006-10-18 接受日期: 2006-12-18
Effects of cholecystokinin and secretin on pancreatic duct pressure and pancreatic blood flow in Australian brush-tailed possums
Cheng-Xian Shi, JWC Chen, J Toouli
Cheng-Xian Shi,Department of General Surgery, Guizhou Provincial Hospital, Guiyang 550002, Guizhou Province, China
JWC Chen, J Toouli,Department of General and Digestive surgery, Flinders University, 5042, Australia
Correspondence to:Cheng-Xian Shi, Department of General Surgery, Guizhou Provincial Hospital, Guiyang 550002, China. chengxianl@yahoo.com.cn
Received:2006-10-18 Accepted:2006-12-18
Abstract
AIM:To investigate the effects of cholecystokinin (CCK) and secretin on pancreatic duct pressure (PDP) and pancreatic blood flow (PBF) in Australian brush-tailed possums.
METHODS:CCK and secretin (5 mg/kg) were intravenously injected into 6 brush-tailed possums respectively. Pancreatic duct of the possums were cannulated and PDP was measured by Maclab recording system separately. PBF was measured using laser Doppler flowmetry.
RESULTS:Five minutes after CCK and secretin injection, PDP increased from 16.2 ± 1.8 and 16.8 ± 1.7 mmHg to 18.9 ± 2.1 and 25.6 ± 1.9 mmHg, and maintained high levels (17.6 ± 2.4 mmHg and 21.5 ± 2.5 mmHg) at the 15th minute (P < 0.002 and P < 0.001); PBF increased from 0.58 ± 0.09 and 0.55 ± 0.04 mL/100 g to 0.75 ± 0.11 and 0.85 ± 0.12 mL/100 g, respectively, at the beginning after CCK and secretin injection. However, CCK and secretin made a continual PDP increase along with PBF decrease till maintaining a low level (0.51 ± 0.09 mL/100 g and 0.39 ± 0.11 mL/100 g, P < 0.001) within 15 minutes, but the influence of secretin was more significant than that of CCK (P < 0.05).
CONCLUSION: PDP can be increased by CCK and secretin injection, resulting in an increase of PBF, which may be the initial factor in the pathogenesis and development of acute biliary pancreatitis.
Key Words: Cholecystokinin; Secretin; Pancreatic duct pressure; Pancreatic blood flow; Possums
Shi CX, Chen JWC, Toouli J. Effects of cholecystokinin and secretin on pancreatic duct pressure and pancreatic blood flow in Australian brush-tailed possums. Shijie Huaren Xiaohua Zazhi 2007;15(6):638-640
摘要目的: 观察缩胆囊素和胰泌素对胰管压力及胰腺血流量的影响, 以探讨急性胆源性胰腺炎的发病机制.
方法: 6只负鼠静脉灌注缩胆囊素和胰泌素5 mg/kg, 分别胰管插管, 并连接到压力感受器上测定胰管压力, 激光多普勒测定胰腺血流量.
结果: 在注射缩胆囊素和胰泌素后5 min, 胰管压力分别由16.2±1.8 mmHg和16.8±1.7 mmHg上升到18.9±2.1 mmHg和25.6±1.9 mmHg, 在随后的5-15 min期间, 胰管压力在此水平缓慢的下降并维持在较高的水平, 分别为17.6±2.4 mmHg和21.5±2.5 mmHg (P<0.002和P<0.001); 胰腺血流量分别由0.58±0.09 mL/100 g和0.55±0.04 mL/100 g上升到0 ......
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