Ezrin、FAK及E-cadherin在大肠癌组织中的表达及其临床意义
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王红建, 史成章, 秦先锋, 黄秋实
大肠癌;埃兹蛋白;黏着斑激酶;上皮细胞钙黏蛋白;侵袭;转移;免疫组化王红建，史成章，秦先锋，黄秋实.Ezrin、FAK及E-cadherin在大肠癌组织中的表达及其临床意义. 世界华人消化杂志2007;15(6)591-595 大肠癌组织中Ezrin,FAK和E-cadher
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王红建, 史成章, 秦先锋, 黄秋实, 郑州大学第一附属医院消化内科 河南省郑州市 450052
王红建, 硕士研究生, 主要从事消化道肿瘤的基础与临床研究.河南省自然科学基金资助项目, No.0511044800
通讯作者: 史成章, 450052, 河南省郑州市, 郑州大学第一附属医院消化内科. scz1679@126.com
电话: 0371-65178797
收稿日期: 2006-11-02 接受日期: 2006-11-21
Expression of ezrin, E-cadherin and focal adhesion kinase in colorectal carcinoma and their clinical significances
Hong-Jian Wang, Cheng-Zhang Shi, Xian-Feng Qin, Qiu-Shi Huang
Hong-Jian Wang, Cheng-Zhang Shi, Xian-Feng Qin, Qiu-Shi Huang, Department of Digestive Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, He’nan Province, China
Supported by the Natural Science Foundation of He’nan Province, No. 0511044800
Correspondence to: Cheng-Zhang Shi, Department of Digestive Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, He’nan Province,China. scz1679@126.com
Received: 2006-11-02 Accepted: 2006-11-21
AbstractAIM:To investigate the expression of ezrin, focal adhesion kinase (FAK) and E-cadherin (E-cad) as well as their correlations with the invasion and metastasis of colorectal carcinoma.
METHODS: Immunohistochemistry was used to detect the expression of ezrin, FAK and E-cad in 50 cases of colorectal carcinoma (including 13 well-differentiated adencarcinomas, 37 moderately- or poorly-differentiated adenocarcinomas; 30 cases without lymph node metastasis and 20 with lymph node metastasis). The correlations among Ezrin, FAK and E-cadherin expression as well as the clinical and pathological characteristics were analyzed by statistical method.
RESULTS: The expression of ezrin was significantly higher in colorectal carcinomas with moderate or poor differention, lymph node metastasis and Dukes C+D stages than that in the ones with high differention, non-metastasis, and Dukes A+B stages (83.78% vs 46.15%, P < 0.01; 95.00% vs 60.00%, P < 0.01; 95.00% vs 60.00%, P < 0.01), but E-cad expression was in the contrary situation (24.32% vs 69.23%, P < 0.01; 10.00%vs 53.33%, P < 0.01; 10.00% vs 53.33%, P < 0.01). The expression of ezrin and E-cad had no marked correlations with the age and sex of patients (P > 0.05). FAK expression was markedly higher in colorectal carcinomas with Dukes C+D stages and lymph node metastasis than that in the ones with Dukes A+B stages and without metastasis (100.00% vs 63.33%, P < 0.01; 100.00% vs 63.33%, P < 0.01), but it had no significant correlation with the differetion degree of tumors, the sex and ages of patients (P > 0.05). Spearman analysis showed that there existed positive correlation between Ezrin and FAK expression (r = 0.346, P < 0.05), and negative correlation between E-cadherin and Ezrin (r = -0.410, P < 0.01) as well as E-cadherin and FAK expression (r = -0.406, P < 0.01).
CONCLUSION: The abnormal expression of ezrin, FAK and E-cad are closely correlated with the infiltration and metastasis of colorectal carcinoma, and the combined detection can be used to judge the prognosis of patients with colorectal carcinoma ......
王红建, 史成章, 秦先锋, 黄秋实, 郑州大学第一附属医院消化内科 河南省郑州市 450052
王红建, 硕士研究生, 主要从事消化道肿瘤的基础与临床研究.河南省自然科学基金资助项目, No.0511044800
通讯作者: 史成章, 450052, 河南省郑州市, 郑州大学第一附属医院消化内科. scz1679@126.com
电话: 0371-65178797
收稿日期: 2006-11-02 接受日期: 2006-11-21
Expression of ezrin, E-cadherin and focal adhesion kinase in colorectal carcinoma and their clinical significances
Hong-Jian Wang, Cheng-Zhang Shi, Xian-Feng Qin, Qiu-Shi Huang
Hong-Jian Wang, Cheng-Zhang Shi, Xian-Feng Qin, Qiu-Shi Huang, Department of Digestive Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, He’nan Province, China
Supported by the Natural Science Foundation of He’nan Province, No. 0511044800
Correspondence to: Cheng-Zhang Shi, Department of Digestive Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, He’nan Province,China. scz1679@126.com
Received: 2006-11-02 Accepted: 2006-11-21
AbstractAIM:To investigate the expression of ezrin, focal adhesion kinase (FAK) and E-cadherin (E-cad) as well as their correlations with the invasion and metastasis of colorectal carcinoma.
METHODS: Immunohistochemistry was used to detect the expression of ezrin, FAK and E-cad in 50 cases of colorectal carcinoma (including 13 well-differentiated adencarcinomas, 37 moderately- or poorly-differentiated adenocarcinomas; 30 cases without lymph node metastasis and 20 with lymph node metastasis). The correlations among Ezrin, FAK and E-cadherin expression as well as the clinical and pathological characteristics were analyzed by statistical method.
RESULTS: The expression of ezrin was significantly higher in colorectal carcinomas with moderate or poor differention, lymph node metastasis and Dukes C+D stages than that in the ones with high differention, non-metastasis, and Dukes A+B stages (83.78% vs 46.15%, P < 0.01; 95.00% vs 60.00%, P < 0.01; 95.00% vs 60.00%, P < 0.01), but E-cad expression was in the contrary situation (24.32% vs 69.23%, P < 0.01; 10.00%vs 53.33%, P < 0.01; 10.00% vs 53.33%, P < 0.01). The expression of ezrin and E-cad had no marked correlations with the age and sex of patients (P > 0.05). FAK expression was markedly higher in colorectal carcinomas with Dukes C+D stages and lymph node metastasis than that in the ones with Dukes A+B stages and without metastasis (100.00% vs 63.33%, P < 0.01; 100.00% vs 63.33%, P < 0.01), but it had no significant correlation with the differetion degree of tumors, the sex and ages of patients (P > 0.05). Spearman analysis showed that there existed positive correlation between Ezrin and FAK expression (r = 0.346, P < 0.05), and negative correlation between E-cadherin and Ezrin (r = -0.410, P < 0.01) as well as E-cadherin and FAK expression (r = -0.406, P < 0.01).
CONCLUSION: The abnormal expression of ezrin, FAK and E-cad are closely correlated with the infiltration and metastasis of colorectal carcinoma, and the combined detection can be used to judge the prognosis of patients with colorectal carcinoma ......
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