雌激素；泌乳素；自身免疫甲状腺疾病____

自身免疫性甲状腺疾病患者血清雌二醇泌乳素检测的临床意义

http://www.100md.com 《实用医技杂志》 2006年第13期

雌激素；泌乳素；自身免疫甲状腺疾病,,],雌激素；泌乳素；自身免疫甲状腺疾病,1对象与方法,2结果,3讨论,参考文献：

     [摘要] 目的:探讨自身免疫性甲状腺疾病(AITD)患者外周血清雌二醇与泌乳素的变化特点及临床意义。方法：采用放射免疫法检测60例AITD患者和20例正常人外周血血清雌二醇和泌乳素的含量。结果：AITD患者血清雌二醇含量高于正常对照(P<0.05),原发性甲亢组与甲低组比较差异无显著性(P>0.05)。血清泌乳素在甲减组明显高于对照组而在甲亢组则与对照比较差异无显著性，甲亢组与甲减组无明显区别。血清雌二醇与泌乳素在AITD患者呈显著性相关(r=0.523,P<0.05)此外，血清雌二醇泌乳素与患者sTSH、TGAb、TMAb之间无显著相关性(r依次为0.208，0.154，0.212)。结论：AITD患者体内存在雌二醇与泌乳素的异常表达，由此加重免疫功能的紊乱，在AITD的发生发展中发挥重要作用。

    [关键词] 雌激素；泌乳素；自身免疫甲状腺疾病

    Detection of Serum E2,PRL in Patients with AITD

    GUO Xiaonan， SONG Changyi，FENG Juanyi,et al

    (Affiliated Second Hospital of Xi'an, Jiaotong university, Xi'an, Shannxi, 710004, China)

    Abstract：Objective To explore the serum concentration of E2,PRL in patients with AITD.Methods Serum levels of E2 and PRL were determined by RIA in 60patients with AITD.Results The serum concentration of E2was significantly increased in AITD patients compared with agematched and gendermatched control subjects(P<0.05),There is no significantly between hyperthyroidism and hypothyroidism(P>0.05).Compared with PRL in the control group,There was no differences in the level of hyperthyroidism and was significantly differences in hypothyroidism.There is also no significantly between hyperthyroidism and hypothyroidism(P>0.05).The serum concentration of E2was positively correlated with the titers of PRL,but not with other parameters(sTSH、TGAb、TMAb).Conclusion The increased serum levels of E2 and PRL in AITD can aggravate the immune disturbance.It suggests that E2 and PRL play an important role in the pathogenesis of AITD. ......

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