环氧化酶2;血管内皮生长因子;尖锐湿疣;免疫组化_

环氧化酶2和血管内皮生长因子在尖锐湿疣组织中的表达及临床病理意义

http://www.100md.com 《实用医技杂志》 2006年第21期

环氧化酶2;血管内皮生长因子;尖锐湿疣;免疫组化,,],环氧化酶2;血管内皮生长因子;尖锐湿疣;免疫组化,1材料与方法,2结果,3讨论,4结论,参考文献：

     [摘要] 目的:探讨尖锐湿疣(CA)组织中环氧化酶2(COX2)和血管内皮生长因子(VEGF)的表达及意义。方法:用免疫组化法分别检测COX2和VEGF蛋白在30例CA组织和10例正常上皮组织中的表达。结果:COX2和VEGF在正常上皮组织均有极少量弱的表达,在CA组织均呈强阳性表达;COX2和VEGF蛋白表达呈正相关。结论:COX2和VEGF表达呈正相关,COX2和VEGF在CA发生、发展中起一定作用,表明COX2可能与肿瘤血管形成有关。

    [关键词] 环氧化酶2;血管内皮生长因子;尖锐湿疣;免疫组化

    Expression and Clinicopathological Significance of COX2 and VEGF Proteinin Condyloma Acuminata

    GUO Ying,LI Hai，CHEN Yin,CHEN Fang,ZHANG Yang

    (The First Hospital of Kunshan City,Kushan,Jiangsu 215300,China)

    Abstract：Objective To detect COX2 and VEGF protein in keratinocytes of condyloma acuminatum(CA),and explore their roles in pathogenesis.Methods The expression of COX2 and VEGF protein in 30 cases of CA and 10 normal controls were detected respectively by immunohistochemistry staining.Results There were no expression of COX2 and VEGF in normal skin tissue,while there were overexpression of COX2 and VEGF in CA tissue;there was a statistically positive correlation between COX2 and VEGF protein overexpression in CA.Conclusion There is a statistically positive correlation between COX2 and VEGF protein overexpression in CA;the study indicated that overexpression of COX2 protein in CA is brelated with tumour blood vessel formation. ......

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