胃肿瘤·白细胞介素1·螺杆菌_幽门·多态性_单核苷酸

IL1基因多态性与胃腺癌发生的关系

http://www.100md.com 《中国现代普通外科进展》 2006年第6期

胃肿瘤·白细胞介素1·螺杆菌,幽门·多态性,单核苷酸,,胃肿瘤·白细胞介素1·螺杆菌，幽门·多态性，单核苷酸,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的：探讨白介素1B(IL1B)和白细胞介素1RN(IL1RN)基因多态性与胃腺癌及幽门螺杆菌(Hp)感染胃腺癌发生发展的相关性。方法：采用基因芯片技术检测130例胃腺癌患者和142例健康对照人群中IL1B31C/T、511C/T位点单核苷酸多态性(SNP)；以琼脂糖凝胶电泳检测IL1RN基因多态性(VNTR)，同时应用酶联免疫吸附试验(ELISA)测定了其血清中HPIgG/IgM/IgA型抗体浓度。结果：感染Hp阳性率胃腺癌明显高于对照组(P=0.007，OR=2.53)。IL1B31TT频率，胃腺癌组明显高于对照组(P<0.05，OR=2.16)，在低分化胃腺癌组明显高于高分化胃腺癌组(P<0.05，OR=6.55)。IL1B511TT基因型频率在胃腺癌组明显高于对照组(P<0.05，OR＝1.81)；在Hp阳性胃腺癌组511TT基因型及T等位基因频率明显高于Hp阴性胃腺癌(P<0.05，OR＝2.25及P<0.05，OR＝1.78)。胃腺癌组TT单体型频率显著高于对照组(χ2＝4.56，P<0.05)。未见IL1RN基因及IL1B其他位点的SNP与胃腺癌组或Hp阳性胃腺癌组有显著相关性。结论：IL1B31TT基因型与胃腺癌特别是低分化胃腺癌易感性相关，IL1B511TT基因型与胃腺癌或感染Hp的胃腺癌易感性相关。TT单体型可能是胃腺癌的遗传易感因素。

    【关键词】胃肿瘤·白细胞介素1·螺杆菌，幽门·多态性，单核苷酸

    Relationship between IL1 gene polymorphisns and gastric adenocarcinoma

    XING Peixiang1,ZENG Qingdong2,GAO Wei3,WANG Yunshan4

    1Department of Clinical Laboratory,2Department of General Surgery,Qilu Hospital of Shandong University(Jinan 250012,China)

    3Department of Oncology, 4 Department of Central Laboratory of Jinan Central Hospital, School of Clinical Medicine of Shandong University(Jinan 250013,China)

    【ABSTRACT】Objective:To investigate relationships between the single nucleotide polymorphisms(SNPs) of interleukin1B(IL1B) and variable number of tandem repeat (VNTR)of interleukin1RN(IL1RN) promoter genes and susceptibility of the patients with gastric adenocarcinoma or the patients with gastric adenocarcinoma to helicobacter pylori (Hp) infection.Methods: ......

百拇医药网 http://www.100md.com/html/DirDu/2007/03/02/37/82/18.htm

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