鼻腔原发性恶性黑色素瘤1例及文献复习
鼻腔肿瘤；恶性黑色素瘤；免疫组织化学；诊断,鉴别,,鼻腔肿瘤；恶性黑色素瘤；免疫组织化学；诊断，鉴别,1病例资料,2病理检查,3讨论,参考文献
【摘 要】 目的 探讨鼻腔原发性恶性黑色素瘤的临床病理特征、组织发生及鉴别诊断。方法 对1例原发于鼻腔恶性黑色素瘤进行光镜观察，并行免疫组化染色标记。结果 组织学特征为：黑色素瘤细胞呈巢状或片状分布，肿瘤细胞大小不一，形态多样。瘤细胞内外可见粗大的黑色素颗粒，免疫表型HMB45、vimentin及S100蛋白肿瘤细胞呈阳性表达。结论 鼻腔原发性恶性黑色素瘤较罕见，诊断必须结合病史、全身检查及随访资料，以排除转移性恶性黑色素瘤。【关键词】 鼻腔肿瘤；恶性黑色素瘤；免疫组织化学；诊断，鉴别
Primary malignant melanoma of nasal cavity: a case report and review of literatures LUO Weimin,CHEN Zhihui,CHEN Yuying.The Department of Pathology,First People's Hospital of Shaoguan City，Guangdong,Shaoguan 512000,China
【Abstract】 Objective To study the clinicopathological feature，histogenesis and differential diagnosis of primary melanoma of the nasal cavity.Methods The histopathological characteristics of a patient with primary malignant melanoma arising from the nasal cavity was analyzed by HE staining,histochemical and immunohistochemical techniques.Results The distribution of melanoma cells showed as sheets and nests.The tumor cells varied in size and shape.Some thick melanin grains were seen in or out of the cells.The expression of HMB45,vimentin and S100 protein were seen in the tumor cells by immunohistochemical stains.Conclusion Primary malignant melanoma of the nasal cavity is rare.It is difficult to distinguish primary from metastatic lesions based on the histopathology alone.Diagnosis of primary melanoma can be made through physic examination and followup the history after metastatic lesions are excluded. ......
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