脑白质疏松；血管内皮生长因子_

脑白质疏松患者血清VEGF水平的研究

http://www.100md.com 《疑难病杂志》 2007年第1期

脑白质疏松；血管内皮生长因子,,脑白质疏松；血管内皮生长因子,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的探讨血管内皮生长因子(VEGF)在脑白质疏松(LA)患者中的临床意义。方法用酶联免疫分析法测定45例LA患者和20例健康人血清VEGF的含量。将LA患者根据其严重程度分为4级，同时又根据是否合并脑梗死分为伴脑梗死组与不伴梗死组，然后比较不同级别和不同组别患者的血清VEGF的含量。结果除LA I组患者血清VEGF的含量与正常对照组比较无统计学意义外，其余3组的VEGF含量均显著高于正常对照组(P<0.01)，而且随脑白质疏松严重程度的加重而血清VEGF的含量也随之明显升高(P<0.05或P<0.01)。伴脑梗死组LA患者血清VEGF含量明显高于不伴脑梗死组(P<0.01)。结论 VEGF与LA的发生发展有着一定的关系，血清VEGF含量可以反映LA的严重程度以及脑缺血的严重性。

    【关键词】脑白质疏松；血管内皮生长因子

    Study on the level of vascular endothelial growth factor in patient with leukoaraiosis WANG Shijie,WANG Daoqiang,LI Fenglian.The People's Hospital of Juancheng,Shandong,Juancheng 274600,China

    【Abstract】 Objective To explore the clinical significance of VEGF in patients with leukoaraiosis (LA).Methods Enzymelinked immunosorbent assay (ELISA) was used for determination of VEGF contents in blood serum in 45 patients with LA and 20 healthy persons.The patients with LA were divided into 4 grades according to degree of leukoaraiosis,and were also divided into two groups in which one with cerebral infarction and the other without cerebral infarction.Then the contents of VEGF in different grades and groups were compared.Results The contents of VEGF in the patients with LA were significantly higher than that in control group (P<0.01) ......

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