阿尔茨海默病；_雌二醇；_黄体生成素；_卵泡刺激素_

绝经后雌激素水平与阿尔茨海默病的关系分析

http://www.100md.com 《实用老年医学》 2007年第1期

阿尔茨海默病；,雌二醇；,黄体生成素；,卵泡刺激素,,阿尔茨海默病；,雌二醇；,黄体生成素；,卵泡刺激素,1资料与方法,2结果,3讨论,[参考文献]

     【摘要】目的探讨绝经后雌激素水平与阿尔茨海默病(AD)的关系。方法绝经后AD女性患者35例，绝经后健康妇女42例，测定血浆雌二醇(E2)水平和黄体生成素(LH)、卵泡刺激素(FSH)水平。结果绝经后AD妇女E2水平较绝经后健康妇女明显下降，差异有显著性统计学意义(P<001);LH和FSH水平在AD组明显上升，AD组和对照组比较差异有显著性意义(P<0.01);而LH、FSH均与E2呈显著负相关(r＝-0902，-0910，P<001)。结论随着血浆E2水平下降，LH、FSH水平上升，AD的发病率增高。

    【关键词】阿尔茨海默病；雌二醇；黄体生成素；卵泡刺激素

    Relationship between estrogen and Alzheimers disease in postmenopausal women

    GUO Rong.

    Department of Neurology, Shenyang Red Cross Hospital,Shenyang 110013,China

    【Abstract】 Objective To study the relationship between estrogen and Alzheimers disease(AD) in postmenopausal women. Methods The plasma levels of estradiol(E2)，luteinizing hormone(LH) and folliclestimulating hormone(FSH) were measured in 35 postmenopausal women with AD and 42 controls. Resukts E2 level in the AD group was lower than that in the controls(P<001),LH and FSH levels in the AD cases were higher than those in the controls(P<001).There was a significant negative correlation between LH ......

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