慢性脑缺血大鼠血清甲状腺激素与其认知障碍变化的关系
Morris水迷宫；,大鼠；,甲状腺激素；,认知功能,,Morris水迷宫；,大鼠；,甲状腺激素；,认知功能,1材料和方法,2结果,3讨论,[参考文献]
【摘要】 目的 研究慢性脑缺血大鼠学习记忆变化及血清甲状腺激素变化关系。 方法 成年SD大鼠随机分为假手术组、单纯手术组、术后治疗组，造模成功5周后用Morris水迷宫测试大鼠学习记忆能力，实验终点放免法测定各组血清甲状腺激素。 结果 水迷宫实验中定位航行试验：单纯手术组较假手术组、术后治疗组逃避潜伏期明显延长(P<005)；空间探索试验：单纯手术组较假手术组显著缩短(P<001)；血清T3浓度单纯手术组较假手术组、术后治疗组明显降低(P<001)。 结论 慢性脑缺血大鼠血甲状腺激素浓度及代谢异常，其变化可能与认知功能相关。【关键词】 Morris水迷宫； 大鼠； 甲状腺激素； 认知功能
Relationship between serum thyroid hormone and cognitive impairment in rats with chronic cerebral ischemia
SHANG Yonghua,WANG Qun,LU Bingxun.
Department of Neurology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou 510515,China；LIU Haiyun. Department of Neurology，Fuzhou General Hospital,Fuzhou 350025,China
【Abstract】 Objective To study the relationship between serum thyroid hormone and cognitive impairment in rats with chronic cerebral ischemia. Methods Twentyfive male SD rats were randomly allocated into sham operation group(SO,n=10),operation group(PO,n=7),thyroid hormone treatment group(THT, n=8).Morris water maze test and T3，T4 concentration detected by radioimmunoassay were performed at the end of experiment. Resukts The average escape latency of PO was significantly longer than that of the other two groups during platform orientation test(P<005), and the probe time of PO was much shorter than that of SO during spatial probe test (P< 001). Serum T3 concentration of PO was significantly lower than that of the other two groups. Conckusions Serum T3 concentration is possibly correlated with congnitive impairment in rats with chronic cerebral ischemia ......
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