【摘 要】 目的 研究抗环瓜氨酸多肽(CCP)抗体对于早期类风湿关节炎(RA)的诊断价值，并探讨应用ELISA法测定抗CCP抗体时不同临床标本对于实验结果的影响。 方法 52例诊断为RA的患者和其他结缔组织病患者60例用ELISA方法检测抗CCP抗体，同时用间接免疫荧光法检测抗角质蛋白抗体(AKA)，并用溶血、高血脂、黄疸标本做干扰实验。 结果 抗CCP抗体对RA诊断的敏感性为59.62%，特异性为96.67%;干扰实验中溶血、高血脂、高浓度黄疸对于检测结果无显著影响(P>0.05);中度黄疸使测定结果下降，有显著性差异(P<0.05)。 结论 抗CCP抗体对于早期RA有极高的诊断价值，联合检测AKA效果更好;ELISA方法检测抗CCP抗体是一种准确灵敏的方法。

    【关键词】 抗环瓜氨酸多肽抗体;抗角质蛋白抗体;类风湿关节炎;干扰因素

    The clinical significance of anti-cyclic critrullinated polypeptide antibody and the analysis of interference fac-tors GAO Lixia，LIU Fengzhen，LIU Xiaolei.Second Hospital of Hebei Medical University，Shijiazhuang 050000，China

    【Abstract】 Objective To study the diagnostic value of anti-cyclic critrullinated polypeptide(CCP)antibody(AKA)for early rheumatoid arthritis and to investigate the influences of different samples on experimental result.Methods The anti-CCP antibody in52patients with RA and60patients with other CTD was detected by ELISA.The anti-keratin antibody(AKA)in these patients was detected by indirect immunofluorescent test.The interference test was done with the samples of hemolysis ......