血管内皮生长因子；_白细胞介素1β；

血清血管内皮生长因子与老年人急性冠状动脉综合征关系探讨

http://www.100md.com 《实用老年医学》 2007年第1期

血管内皮生长因子；,白细胞介素1β；,老年人；,急性冠状动脉综合征；,缺血,,血管内皮生长因子；,白细胞介素1β；,老年人；,急性冠状动脉综合征；,缺血,1对象与方法,2结果,3讨论,[参考文献]

     【摘要】目的观察老年急性冠状动脉综合征(ACS)及中年ACS患者血清血管内皮生长因子(VEGF)和白细胞介素1β(IL1β)水平是否存在差别，为老年ACS的防治提供一种新的方法。方法选择年龄>65岁的老年冠心病患者60例，其中稳定型心绞痛(SAP)30例(A组)，ACS患者30例(B组)。选择中年ACS患者30例(C组)，中年健康人30例(D组)，均于入院第3天抽取空腹静脉血测定血清VEGF及IL1β的水平。结果 B组及C组的血清VEGF及IL1β的水平明显高于A组及D组，差异具有统计学意义(P<001)。C组的血清VEGF及IL1β的水平高于B组，差异亦具有统计学意义(P<001或P<005)。ACS患者血清IL1β及VEGF的水平具有正相关关系。结论老年ACS及中年ACS的血清VEGF及IL1β的水平均高于SAP患者及中年健康人，这是由于发病时心脏缺血缺氧所致，但老年ACS的血清VEGF及IL1β的水平低于中年ACS，这是由于衰老影响了血清VEGF及IL1β的含量。ACS患者血清IL1β及VEGF的水平具有正相关关系。

    【关键词】血管内皮生长因子；白细胞介素1β；老年人；急性冠状动脉综合征；缺血

    Correlation between vascular endothelial growth factor and acute coronary syndromes in the elderly

    LIU Yongsheng, WEI Mei.

    Department of Clinics and Cardiology,the First Hospital of Qinhuangdao, Qinhuangdao 066000,China; CAO Zhichen. Department of Combination of Chinese Medicine and Western Medicine, the Third Hospital of Hebei Medical University, Shijiazhuang 066000,China

    【Abstract】 Objective To investigate the differences of the serum levels of VEGF and IL1β between the aged patients with acute coronary syndromes (ACS) and middleaged ACS patients in order to find a method of preventing and treating ACS. Methods Sixty elderly patients with coronary heart disease aged over 65 years were assigned to group A[30 patients with stable angina pectoris(SAP)] and group B(30 patients with ACS).Thirty middleaged ACS patients were enrolled in group C and 30 healthy middleaged people were enrolled in group D.Blood samples were taken from the peripheral vein in every patient on the third day after admission.The serum levels of VEGF and IL1β were determined by method of ELISA Assay. Resukts Levels of VEGF and IL1β in group B and group C were higher than those in group A and group D. There was significant difference between group B,C and group A,D. Levels of VEGF and IL1β in group C were higher than those in group B. There was significant difference between group B and group C. The level of VEGF showed positive correlation with IL1β level in ACS patients. Conckusions The levels of VEGF and IL1β in aged ACS patients and middleaged ACS patients are higher than those in aged SAP patients and healthy middleaged people because of anoxia and ischenia in the hearts of aged ACS patients.But compared with the middleaged ACS patients,the serum levels of VEGF and IL1β in aged ACS patients are lower ......

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