亚砷酸；_老年；_恶性血液病_____亚砷酸；

亚砷酸治疗老年恶性血液病的初步观察

http://www.100md.com 《实用老年医学》 2007年第1期

亚砷酸；,老年；,恶性血液病,,亚砷酸；,老年；,恶性血液病,1资料与方法,2结果,3讨论,[参考文献]

     【摘要】目的探讨亚砷酸在治疗老年恶性血液病的临床疗效及不良反应。方法对40例≥60岁的恶性血液病患者，应用亚砷酸治疗(10 mg/d,静脉点滴，28 d为1疗程，如不良反应明显则改为14 d短疗程，间隔14 d后再用14 d，2次为1疗程)。观察其临床疗效及不良反应。结果急性早幼粒细胞白血病(APL)：完全缓解(CR) 8例，其他急性非淋巴细胞白血病(ANLL)CR 1例，部分缓解(PR)1例，未缓解(NR)6例；慢性粒细胞白血病(CML)：PR 4例，NR 2例；慢性淋巴细胞白血病(CLL)：CR 1例、PR 1例；B细胞非霍奇金淋巴瘤(NHL)：CR 1例，PR 2例，进步1例，无效1例；骨髓增生异常综合征(MDS)：PR 2例，进步2例，无效1例；慢性粒单细胞白血病(CMML)：CR 2例，PR 2例；多发性骨髓瘤(MM)：PR 1例，进步1例。所有病例总有效率为75%。仅2例因严重肝损、骨髓抑制而停药，无用亚砷酸相关死亡病例。结论对不能耐受强化疗的老年难治/复发的血液肿瘤患者，亚砷酸具有一定的治疗效果，且不良反应相对较低。

    【关键词】亚砷酸；老年；恶性血液病

    Effects of arsenic trioxide on hematology malignancy in elderly patients

    PANG Ying，FENG Ying，CAI Xiaodong，YE Xu.

    Department of Hematology，the 2nd Affiliated Hospital of Guangzhou Medical College，Guangzhou 510260，China； SHEN Zhixiang. Institute of Hematology，Ruijin Hospital of Shanghai Jiaotong University，Shanghai 200023，China

    【Abstract】 Objective To evaluate the therapeutic effect and adverse effects on elderly patients with malignant hematology. Methods Forty elderly patients aged over 60 with hematology malignancy were enrolled in the present study. Arsenic trioxide was given as IV infusion for 28 days. The patients who could not tolerate 28day regimen due to drug toxicity would receive the same dose of arsenic trioxide for 14 days, undergo a 14day break to recover, and then complete the rest of the regimen in another 14 days. Therapeutic effect and toxicity of arsenic trioxide were observed throughout the entire clinical period. Resukts The overall effective rate for the cases enrolled was 78%. All of the 8 patients with acute promyelocytic leukemia(APL) achieved complete remission (CR). Among the 8 ANLL patients with nonAPL , 1 case had CR and 1 of them had partial remission(PR) ......

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