Cajal_间质细胞；KIT蛋白；小肠；腹膜炎____

急性细菌性腹膜炎对豚鼠小肠Cajal间质细胞的影响

http://www.100md.com 《局解手术学杂志》 2007年第1期

Cajal,间质细胞；KIT蛋白；小肠；腹膜炎,,],Cajal,间质细胞；KIT蛋白；小肠；腹膜炎,1材料与方法,2结果,3讨论,[参考文献]

     [摘要]目的探讨豚鼠腹膜炎模型中小肠Cajal间质细胞网络的变化情况。方法利用腹腔内注射大肠杆菌和10%BaSO4肉汤佐剂的方法建立腹膜炎模型，冰冻切片和全层铺片并结合KIT免疫细胞化学染色观察。结果腹膜炎12～24 h，腹膜炎症状最明显，在切片和铺片上均可见ICCs明显减少，其中ICMY减少最显著，48～96 h后ICCs的数量逐渐恢复正常，同时豚鼠的腹膜炎反应也减轻甚至康复。结论小肠壁内ICCs在腹膜炎模型中可明显减少，但随着时间延长，ICCs逐渐恢复正常的细胞网络。

    [关键词] Cajal 间质细胞；KIT蛋白；小肠；腹膜炎

    Effects of acute bacterial peritonitis on interstitial cells of Cajal in intestinal wall of the guinea pigs

    GONG Bin, MEI Longcun

    (the Second People’s Hospital of Yubei District, Chongqing 401147, China)

    Abstract: ObjectivesTo investigate the changes of interstitial cells of Cajal networks in the guinea pigs model of acute bacterial peritonitis. MethodsPeritonitis models were carried out by injection of bacterium coli and 10% BaSO4 broth adjuvant, ICCs were observed on the frozen sections and wholemount preparation with KIT immunohistochemistry. Results12~24 hours after peritonitis, symptoms of peritonitis were observed and ICCs decreased obviously on both frozen sections and wholemount preparation, especially for ICMY, while 2~4 days later the number and distribution of ICCs restored to normal.ConclusionAcute bacterial peritonitis might lead to temporary loss of ICCs, and it would be soon recovered. ......

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