机械通气；呼吸频率；肺损伤_

机械通气呼吸频率变化相关肺损伤的实验研究

http://www.100md.com 《第四军医大学学报》 2007年第3期

机械通气；呼吸频率；肺损伤,,机械通气；呼吸频率；肺损伤,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Effect of respiratory rate of mechanical ventilation on lung injury in rabbits

    LIU Ying, SHI JianGuo,WANG Bo

    Department of Thoracic Surgery，PLA General Hospital， Beijing 100853, China, Department of Pathology, School of Basic Medicine, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM： To investigate the effect of respiratory rate of mechanical ventilation on lung injury in rabbits. METHODS: Twentyfour New Zealand white rabbits were randomly divided into 3 groups: high respiratory rate group (40 times/min), low respiratory rate group (8 times/min) and normal control group (15 times/min)， each group including 8 animals. The 3 groups were ventilated with tidal volume of 15 mL/kg body weight, FiO2 of 0.5, inspiratory time (I) of 25% and inspiratory pause time (P) of 10%. The indexes including mean artery blood pressure (MAP)， heart beat (HR)， PaO2， PaCO2， pH， airway peak pressure (Ppeak)， plat pressure (Pplat) and lung compliance (Cst) were measured at 30， 60， 90 and 120 min during ventilation. The animals were sacrificed by draining artery blood at the end of experiment. Total cells from irrigating solution of left lung were counted. Partial right lung was cut off for pathological examination ......

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