二十岁以下慢性HBV感染者HBV DNA与HBeAg的定量关系
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吴殿磊, 徐光华, 冯继红, 樊 霞, 苗乃周, 刘晓斌, 陈天艳, 张树林
20岁以下患者;慢性HBV感染;HBVDNA;HBeAg,二十岁以下慢性HBV感染者HBVDNA与HBeAg的定量关系,吴殿磊,徐光华,冯继红,樊霞,苗乃周,刘晓斌,陈天艳,张树林,通讯作者:,电话:,收稿日期:,接受日期:,Correlationbetweenhepati
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吴殿磊, 徐光华, 冯继红, 延安大学附属医院感染病科 陕西省延安市 716000
樊霞, 延安大学医学院卫生统计学教研室 陕西省延安市 716000
苗乃周, 延安大学医学院组胚教研室 陕西省延安市 716000
刘晓斌, 延安大学医学院医技系检验教研室 陕西省延安市 716000
陈天艳, 张树林, 西安交通大学医学院第一附属医院感染病科 陕西省西安市 710061
通讯作者: 徐光华, 716000, 陕西省延安市, 延安大学附属医院感染病科. yaxugh@yahoo.com.cn
电话: 0911-2881196
收稿日期: 2006-11-23 接受日期: 2007-01-20
Correlation between hepatitis B virus DNA levels and HBeAg quantity in patients under 20 years old with chronic hepatitis B virus infection
Dian-Lei Wu, Guang-Hua Xu, Ji-Hong Feng, Xia Fan, Nai-Zhou Miao, Xiao-Bin Liu, Tian-Yan Chen, Shu-Lin Zhang
Dian-Lei Wu, Guang-Hua Xu, Ji-Hong Feng,Department of Infectious Diseases, the Affiliated Hospital of Yan’an University, Yan’an 716000, Shaanxi Province, China
Xia Fan,Department of Health Statistics, Medical College of Yan’an University, Yan’an 716000, Shaanxi Province, China
Nai-Zhou Miao,Department of Histology and Embryology, Medical College of Yan’an University, Yan’an 716000, Shaanxi Province, China
Xiao-Bin Liu,Department of Laboratory Medicine and Biotechnology, Medical College of Yan’an University, Yan’an 716000, Shaanxi Province, China
Tian-Yan Chen, Shu-Lin Zhang,Department of Infectious Diseases, the First Affiliated Hospital of Medical College of Xi,an jiaotong University, Xian 710061 shaanxi province China
Correspondence to:Guang-Hua Xu, Department of Infectious Diseases, the Affiliated Hospital of Yan’an University, Yan’an 716000, Shaanxi Province, China.
yaxugh@yahoo.com.cn
Received:2006-11-23 Accepted: 2007-01-20
AbstractAIM:To investigate the relationshipt between hepatitis B virus (HBV) DNA contents and HBeAg quantity in HBV-infected patients under 20 years old.
METHODS: The serum HBV DNA contents and HBeAg quantity in 339 patients (age 1-20) with chronic HBV infection were examined by real time fluorescence quantitative polymerase chain reaction (FQ-PCR) and time-resolved fluoroimmunoassay (TRFIA) respectively, and the level of anine aminotransferase (ALT) was detected by rate method.
RESULTS: The patients with HBV DNA contents more than 105 copies/mL, HBeAg quantity more than 0.3 NCU/mL, and normal ALT level accounted for 92.3% of the total cases. Positive correlation (r = 0.769, P < 0.001) and linear regression (b = 0.32, R2 = 0.59, P < 0.001) existed between HBV DNA contents (on a log scale) and HBeAg quantity in the patients under 20 years old.
CONCLUSION: Serum HBV DNA contents and HBeAg quantity are changed simultaneously in HBV-infected patients under 20 years old, except in quite a few cases, so combined examination of HBV DNA and HBeAg may help to evaluate the state of chronic HBV infection more exactly.
Key Words: Patients under 20 years old; Chronic hepatitis B virus infection; Hepatitis B virus DNA; HBeAg; Correlation ......
吴殿磊, 徐光华, 冯继红, 延安大学附属医院感染病科 陕西省延安市 716000
樊霞, 延安大学医学院卫生统计学教研室 陕西省延安市 716000
苗乃周, 延安大学医学院组胚教研室 陕西省延安市 716000
刘晓斌, 延安大学医学院医技系检验教研室 陕西省延安市 716000
陈天艳, 张树林, 西安交通大学医学院第一附属医院感染病科 陕西省西安市 710061
通讯作者: 徐光华, 716000, 陕西省延安市, 延安大学附属医院感染病科. yaxugh@yahoo.com.cn
电话: 0911-2881196
收稿日期: 2006-11-23 接受日期: 2007-01-20
Correlation between hepatitis B virus DNA levels and HBeAg quantity in patients under 20 years old with chronic hepatitis B virus infection
Dian-Lei Wu, Guang-Hua Xu, Ji-Hong Feng, Xia Fan, Nai-Zhou Miao, Xiao-Bin Liu, Tian-Yan Chen, Shu-Lin Zhang
Dian-Lei Wu, Guang-Hua Xu, Ji-Hong Feng,Department of Infectious Diseases, the Affiliated Hospital of Yan’an University, Yan’an 716000, Shaanxi Province, China
Xia Fan,Department of Health Statistics, Medical College of Yan’an University, Yan’an 716000, Shaanxi Province, China
Nai-Zhou Miao,Department of Histology and Embryology, Medical College of Yan’an University, Yan’an 716000, Shaanxi Province, China
Xiao-Bin Liu,Department of Laboratory Medicine and Biotechnology, Medical College of Yan’an University, Yan’an 716000, Shaanxi Province, China
Tian-Yan Chen, Shu-Lin Zhang,Department of Infectious Diseases, the First Affiliated Hospital of Medical College of Xi,an jiaotong University, Xian 710061 shaanxi province China
Correspondence to:Guang-Hua Xu, Department of Infectious Diseases, the Affiliated Hospital of Yan’an University, Yan’an 716000, Shaanxi Province, China.
yaxugh@yahoo.com.cn
Received:2006-11-23 Accepted: 2007-01-20
AbstractAIM:To investigate the relationshipt between hepatitis B virus (HBV) DNA contents and HBeAg quantity in HBV-infected patients under 20 years old.
METHODS: The serum HBV DNA contents and HBeAg quantity in 339 patients (age 1-20) with chronic HBV infection were examined by real time fluorescence quantitative polymerase chain reaction (FQ-PCR) and time-resolved fluoroimmunoassay (TRFIA) respectively, and the level of anine aminotransferase (ALT) was detected by rate method.
RESULTS: The patients with HBV DNA contents more than 105 copies/mL, HBeAg quantity more than 0.3 NCU/mL, and normal ALT level accounted for 92.3% of the total cases. Positive correlation (r = 0.769, P < 0.001) and linear regression (b = 0.32, R2 = 0.59, P < 0.001) existed between HBV DNA contents (on a log scale) and HBeAg quantity in the patients under 20 years old.
CONCLUSION: Serum HBV DNA contents and HBeAg quantity are changed simultaneously in HBV-infected patients under 20 years old, except in quite a few cases, so combined examination of HBV DNA and HBeAg may help to evaluate the state of chronic HBV infection more exactly.
Key Words: Patients under 20 years old; Chronic hepatitis B virus infection; Hepatitis B virus DNA; HBeAg; Correlation ......
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