感染后肠易激综合征与溃疡性结肠炎缓解期患者肠黏膜细胞因子表达的相关性
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鞠 辉, 刘希双, 王光兰, 尹晓燕, 刘 华, 戴素美
肠易激综合征;溃疡性结肠炎;P物质;细胞因子,鞠辉,刘希双,王光兰,尹晓燕,刘华,戴素美,鞠辉,通讯作者:,电话:,收稿日期:,接受日期:,Correlationbetweenpost-infectiveirrita
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鞠辉, 刘希双, 王光兰, 尹晓燕, 刘华, 戴素美, 青岛大学医学院附属医院内镜诊治中心 山东省青岛市 266003
鞠辉, 2006年青岛大学医学院消化内科专业硕士, 主要从事消化内窥镜诊治工作.
通讯作者: 刘希双, 266003, 山东省青岛市, 青岛大学医学院附属医院内镜诊治中心. liuxishuang1@sina.com
电话: 0532-82911525
收稿日期: 2006-12-23 接受日期: 2007-01-25
Correlation between post-infective irritable bowel syndrome and cytokine expression in intestinal mucosa of patients with ulcerative colitis in remission
Hui Ju, Xi-Shuang Liu, Guang-Lan Wang, Xiao-Yan Yin, Hua Liu, Su-Mei Dai
Hui Ju, Xi-Shuang Liu, Guang-Lan Wang, Xiao-Yan Yin, Hua Liu, Su-Mei Dai,Center of Endoscopic Diagnosis and Therapy, the Affiliated Hospital of Qingdao University Medical School, Qingdao 266003, Shandong Province, China
Correspondence to:Xi-Shuang Liu, Center of Endoscopic Diagnosis and Therapy, the Affiliated Hospital of Qingdao University Medical School, Qingdao 266003, Shandong Province, China. liuxishuang1@sina.com
Received:2006-12-23 Accepted:2007-01-25
AbstractAIM: To investigate whether the mucosal cytokines is differently expressed between post-infective irritable bowel syndrome (PI-IBS) and ulcerative colitis (UC) in remission.
METHODS: SABC immunohistochemistry was used to detect the mucosal expression of substance P (SP), interleukin-2 (IL-2), and interferon-γ (IFN-γ) in 26 PI-IBS patients, 45 UC patients, and 30 controls.
RESULTS: The positive rates of mucosal IFN-γ, IL-2 and SP were significantly higher in the descending colon and rectum of PI-IBS patients than those in the controls (IFN-γ: χ2 = 13.781, 14.012, P < 0.01; IL-2: χ2 = 13.890, 13.931, P < 0.01; SP intensity: t = 3.623, 3.722, P < 0.01; SP area: t = 3.454, 3.561, P < 0.01), but not markedly different from those in UC patients. The SP intensity and area were also significantly higher in the IFN-γ- and IL-2-positive descending colon and rectum of PI-IBS patients than those in the controls (intensity: t = 2.202, 2.220, P < 0.05; area: t = 2.301, 2.252, P < 0.05), but not notably different from those in UC patients.
CONCLUSION: The cytokine expression has no marked difference between PI-IBS and UC. There may be some correlation between PI-IBS and inflammatory bowel disease (IBD), and IBS is probably a low-grade IBD according to neuroimmune mechanism.
Key Words: Irritable bowel syndrome; Ulcerative colitis; Substance P; Cytokine
Ju H, Liu XS, Wang GL, Yin XY, Liu H, Dai SM. Correlation between post-infective irritable bowel syndrome and cytokine expression in intestinal mucosa of patients with ulcerative colitis in remission. Shijie Huaren Xiaohua Zazhi 2007;15(8):844-848
摘要目的: 探讨感染后肠易激综合征(PI-IBS)与溃疡性结肠炎(UC)缓解期患者结肠黏膜细胞因子表达的相关性.
方法: PI-IBS组26例, UC组45例及对照组30例, 结肠镜下活检降结肠和直肠黏膜标本, 采用免疫组化SABC法检测其肠黏膜P物质(SP)与IL-2, IFN-γ的表达情况.
结果: PI-IBS组降结肠和直肠黏膜IFN-γ和IL-2阳性率表达、SP强度均值和面积高于对照组(IFN-γ: χ2 = 13 ......
鞠辉, 刘希双, 王光兰, 尹晓燕, 刘华, 戴素美, 青岛大学医学院附属医院内镜诊治中心 山东省青岛市 266003
鞠辉, 2006年青岛大学医学院消化内科专业硕士, 主要从事消化内窥镜诊治工作.
通讯作者: 刘希双, 266003, 山东省青岛市, 青岛大学医学院附属医院内镜诊治中心. liuxishuang1@sina.com
电话: 0532-82911525
收稿日期: 2006-12-23 接受日期: 2007-01-25
Correlation between post-infective irritable bowel syndrome and cytokine expression in intestinal mucosa of patients with ulcerative colitis in remission
Hui Ju, Xi-Shuang Liu, Guang-Lan Wang, Xiao-Yan Yin, Hua Liu, Su-Mei Dai
Hui Ju, Xi-Shuang Liu, Guang-Lan Wang, Xiao-Yan Yin, Hua Liu, Su-Mei Dai,Center of Endoscopic Diagnosis and Therapy, the Affiliated Hospital of Qingdao University Medical School, Qingdao 266003, Shandong Province, China
Correspondence to:Xi-Shuang Liu, Center of Endoscopic Diagnosis and Therapy, the Affiliated Hospital of Qingdao University Medical School, Qingdao 266003, Shandong Province, China. liuxishuang1@sina.com
Received:2006-12-23 Accepted:2007-01-25
AbstractAIM: To investigate whether the mucosal cytokines is differently expressed between post-infective irritable bowel syndrome (PI-IBS) and ulcerative colitis (UC) in remission.
METHODS: SABC immunohistochemistry was used to detect the mucosal expression of substance P (SP), interleukin-2 (IL-2), and interferon-γ (IFN-γ) in 26 PI-IBS patients, 45 UC patients, and 30 controls.
RESULTS: The positive rates of mucosal IFN-γ, IL-2 and SP were significantly higher in the descending colon and rectum of PI-IBS patients than those in the controls (IFN-γ: χ2 = 13.781, 14.012, P < 0.01; IL-2: χ2 = 13.890, 13.931, P < 0.01; SP intensity: t = 3.623, 3.722, P < 0.01; SP area: t = 3.454, 3.561, P < 0.01), but not markedly different from those in UC patients. The SP intensity and area were also significantly higher in the IFN-γ- and IL-2-positive descending colon and rectum of PI-IBS patients than those in the controls (intensity: t = 2.202, 2.220, P < 0.05; area: t = 2.301, 2.252, P < 0.05), but not notably different from those in UC patients.
CONCLUSION: The cytokine expression has no marked difference between PI-IBS and UC. There may be some correlation between PI-IBS and inflammatory bowel disease (IBD), and IBS is probably a low-grade IBD according to neuroimmune mechanism.
Key Words: Irritable bowel syndrome; Ulcerative colitis; Substance P; Cytokine
Ju H, Liu XS, Wang GL, Yin XY, Liu H, Dai SM. Correlation between post-infective irritable bowel syndrome and cytokine expression in intestinal mucosa of patients with ulcerative colitis in remission. Shijie Huaren Xiaohua Zazhi 2007;15(8):844-848
摘要目的: 探讨感染后肠易激综合征(PI-IBS)与溃疡性结肠炎(UC)缓解期患者结肠黏膜细胞因子表达的相关性.
方法: PI-IBS组26例, UC组45例及对照组30例, 结肠镜下活检降结肠和直肠黏膜标本, 采用免疫组化SABC法检测其肠黏膜P物质(SP)与IL-2, IFN-γ的表达情况.
结果: PI-IBS组降结肠和直肠黏膜IFN-γ和IL-2阳性率表达、SP强度均值和面积高于对照组(IFN-γ: χ2 = 13 ......
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