喹诺酮类药物致老年患者神经系统不良反应分析
喹诺酮类；,神经系统；,不良反应；,老年人,【主题词】喹诺酮类；神经系统；不良反应；老年人,1资料和方法,2结果,3讨论,参考文献
【摘要】 目的 分析120例老年患者应用喹诺酮类药物引起神经系统的不良反应(ADR)特点。 方法 从我院历年的患者ADR报告中，选出≥60岁的老年患者ADR报告表，逐项统计整理。 结果 老年患者神经系统ADR男性多于女性，严重程度以轻、中度多见；临床表现以头晕、失眠为主，分列第一、二位，最易引起神经系统ADR的药物为左氧氟沙星；静脉用药最易引起神经系统的ADR。 结论 老年患者在应用喹诺酮类药物治疗中，神经系统的ADR与患者的年龄、给药途径密切相关。【主题词】 喹诺酮类； 神经系统； 不良反应； 老年人
Analysis of adverse drug reactions of fluoroquinolones on nervous system in elderly patients
Li Hongbiao.
Department of Neurology,Wuxi Elderly Disease Hospital,Wuxi 214021 China
【Abstract】 Objective To analyze adverse reactions of fluoroquinolones on nervous system and the related factors in 120 elderly patients. Methods Reports about adverse drug reaction (ADR)over years in this hospital were collected and reviewed. Patients with ADR were all over 60 years . Resukts ADR on nervous system in elderly patients developed more often in male than in female.Most cases had light or medium reaction,and the main symptoms of ADR of fluoroquinolones were dizziness and insomnia.Levofoxacin caused more cases of ADR on nervous system than other fluoroquinolones,and intravenous infusion developed more ADR than other ways of administration. Conckusions Developement of ADR on nervous system caused by fluoroquinolones in elderly patients is closely related with their age and the way of administration. ......
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