大肠癌；_HLAI；免疫组化____

大肠癌组织HLAI基因蛋白的表达及意义

http://www.100md.com 《河北医药》 2006年第1期

大肠癌；,HLAI；免疫组化,,大肠癌；,HLAI；免疫组化,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的探讨大肠癌组织HLAI蛋白的表达。方法 41例大肠癌组织中，14例是高分化腺癌，17例是中分化腺癌，10例是低分化腺癌。用抗HLAI抗原的单克隆抗体做免疫组织化学分析。结果阳性组织中细胞膜和细胞浆着色。HLAI在大肠组织中阳性表达率为36.59%，在正常组织中阳性表达率为80%，P<0.05。在不同组织学分级中，HLAI表达有统计学差异，P<0.05。在淋巴结转移与否的癌组织中HLAI表达无统计学差异，P>0.05。结论大肠癌组织中HLAI基因蛋白表达下降，不同组织学分级表达有统计学差异，淋巴结转移与否无统计学差异。

    【关键词】大肠癌； HLAI；免疫组化

    The protein expression of HLAI on colorectal carcinoma

    ZHANG Guojian,YAN Qinghui,WANG Fengan,et al.

    Department of Surgery,Second Hospital of Hebei Medical University,Shijiazhuang 050000

    【Abstract】 Objective To measure the protein expression of human leukocyte antigen class Ⅰ on colorectal carcinoma.Methods Among 41 colorectal carcinoma cases,14 cases were well differentiated adenocarcinoma,17 cases were moderate differentiated ones and 10 were low differentiated ones.HLAI antigens were detected by immunohistochemistry using monoclonal antibody against HLAI antigens.Results The expression of HLAI on the positive cell membrane and cytoplasmic expression were observed.The positive rate of HLAI was 36.59% in colorectal carcinoma.Which was 80% in normal tissues.There was a significant difference between two groups (P<0.05).The expression of HLAI in cancer tissues was correlated statistically with the degree of differentiation (P<0.05).The expression in cases with lymph node metastasis was not correlated statistically with those without lymph node metastasis (P>0.05).Conclusion The expression of HLAI is lower in colorectal carcinoma than that in normal tissues and positively correlated with histological grade of cancer,but not with lymph node metastasis. ......

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