Alterations of serum leptin, interleukinª²6, Cª²reactive protein during lower limb peripheral arterial disease in patients with type 2 diabetes

    XIE Xiaoª²Min, LIU Huiª²Li, YU Liª²Ping, LI Renª²Da, ZHOU Haiª²Yan,ZHANG Li, ZENG Bin, LI Ling, SHI Jing, NIU Xuª²Dong, HOU Qingª²Ning, ZOU Xiaoª²Yan

    Department of Endocrinology, Second Affiliated Hospital, Ningxia Medical College, Yinchuan 750001, China

    ¡¾Abstract¡¿AIM: To investigate the association of leptin, interleukinª²6, Cª²reactive protein with lower limb peripheral arterial disease (PAD) in patients with type 2 diabetes (T2DM). METHODS: A total of 125 T2DM patients were investigated with Bª²mode ultrasonography. Serum markers were measured .These clinical data and age,the duration of diabetes and ankle brachial index (ABI) were analyzed and compared among the patients with PAD (n=65), without PAD (n=60) and the controls (n=50). RESULTS: ¢Ù The duration of diabetes, Tc, ApoB were significantly increased in the patients with PAD compared with the ones without PAD and the normal controls (P<0.01, P<0.05). The ABI were decreased in the patients with PAD compared with the ones without PAD (P<0.01). ¢Ú In the patients with PAD, the serum levels of CRP, LEP were significantly higher than those of the ones without PAD (P<0.01). In the patients with PAD and without PAD, the serum levels of CRP, ILª²6 were significantly higher than those of the normal controls (P<0.01). CONCLUSION: The serum levels of CRP, ILª²6, LEP increased in T2DM patients with PAD. Serum levels of ABI, CRP, ILª²6, LEP should be measured earlier in T2DM patients who have long term duration and blood lipid disorders so as to prevent the occurrence of PAD. ......