多房棘球绦虫；重组BCGEmⅡ(研究原著)

多房棘球绦虫混合重组BCGEmⅡ/3和BCGEm1433疫苗抑制小鼠脾细胞的凋亡

http://www.100md.com 《第四军医大学学报》 2007年第4期

多房棘球绦虫；重组BCGEmⅡ,3疫苗；重组BCGEm1433疫苗；脾,细胞学；细胞凋亡,,多房棘球绦虫；重组BCGEmⅡ,3疫苗；重组BCGEm1433疫苗；脾,细胞学；细胞凋亡,【关键

     Inhibition on apoptosis of splenocytes in mice immunized with mixed rBCGEmⅡ/3 and rBCGEm1433 vaccine against Echinococcus multilocularis

    LI WenGui, WANG Hong, ZHU YouMing

    Institute of Infectious and Parasitic Diseases, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China

    【Abstract】 AIM: To immunize mice with mixed rBCGEmⅡ/3 and rBCGEm1433 vaccine against Echinococcus multilocularis(Em) and to investigate the apoptosis of spleen cells challenged with Em protoscoleces. METHODS: Balb/c mice were vaccinated subcutaneously and intranasally with mixed rBCG vaccines respectively. Eighteen weeks after challenged with Em protoscoleces the mice were killed to take the spleen. The spleen cells were isolated to measure apoptotic rate by flow cytometry. Blank vector, BCG and PBS served as controls. RESULTS: Apoptotic rate in the immunization group was lower than that in the PBS control group (P<0.01). CONCLUSION: Apoptosis of spleen cells in mice may be induced by infection with alveolar hydatid cyst, but it can be inhibited by immunization with mixed rBCGEmⅡ/3 and rBCGEm1433 vaccine. ......

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