Expressions and significances of luteinizing hormone and its receptor in human endometrial cancer

    CHEN Lei1, BAI Hongª²Wei2, YIN Shanª²De1, CHENG Luan1, ZHAO Jun1, SUN Xuª²De3, WANG Aiª²Ming1

    1Department of Gynaecology and Obstetrics, 2Department of Hepatobiliary Surgery, Naval General Hospital, Beijing 100037, China, 3Department of Anaesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi¬ð an 710038, China

    ¡¾Abstract¡¿AIM: To study the localization and distribution of luteinizing hormone (LH) and its receptor (LHR) in human endometrial cancer of various differentiation grades. METHODS: LH and its receptor were detected in 15 endometrial cancers by immunohistochemical methods(HE staining, SABC). RESULTS: LH and its receptor had the same distribution pattern in the tissues of endometrial cancer. The positive signals were mainly located in the membrane and the cytoplasm of adenocarcinoma cells, but not in the nuclei. The positive intensity was also gradually increased along with the differentiation from low to highª²grade adenocarcinoma (P<0.05). CONCLUSION: The endometrioid adenocarcinoma cells may not only produce LH but express HLR. Their expressions are associated with the differentiation grades of human endometrial cancer. ......