Genetic investigation of essential hypertension of Han populations in Kailuan coal mine

    SHEN Zhiª²Xia1, LI Hongª²Fen1, REN Yan1, WANG Xiuª²Yan2, WU Shouª²Ling3

    1Department of Clinical Laboratory, 2Department of Neurology, 3Department of Cardiology, Affiliated Kailuan Hospital, North China Coal Medical College, Tangshan 063000, China

    ¡¾Abstract¡¿ AIM: To study the role that the angiotensinogen (AGT ) gene plays in the pathogenesis of essential hypertension (EH) and investigate the possible association between the AGT gene and the susceptibility to EH in Han populations of Kailuan coal mine. METHODS: The polymerase chain reactionª²restriction fragment length polymorphism (PCRª²RFLP) was used to detect the genotype frequency and polymorphism of the T704C SNP of AGT gene in 1224 individuals. The relationship between the AGT gene and the susceptibility to ET family was analyzed. RESULTS: The prevalence of hypertension in the individuals with family EH history was higher than the ones without family EH history (23.3% vs 14.8%, P<0.01). The prevalence of hypertension in the individuals carrying the homozygote for C alleles was higher compared to the individuals with wild type TT genotype (OR=5.30, 95%, CI:2.40¡«11.74); although the prevalence in the individuals carrying TC genotype was higher than the ones carrying TT genotype ,there was no statistically difference (P>0.05); the difference in the individuals with family EH history was more remarkable(OR=13.56, 95%, CI: 2.96~62.18). CONCLUSION: Hereditary factor plays an important role in the development of EH and AGT gene may be one of the most key susceptibility genes of EH in Han populations of Kailuan coal mine. ......