Preventive and therapeutical effect of the kernel of zanthoxylum seed oil on experimental hyperlipidemia in rats

    LIU Yongª²Ying1,2, WANG Duoª²Ning3, LIU Yuanª²Sheng1£¬YANG Ying3£¬ZHAO Yanª²Wu4£¬WANG Zengª²Lu5, YANG Jiª²Qing1

    1Department of Physics, School of Biomedical Engineering, Fourth Military Medical University, Xi¬ðan 710033, China, 2Xi¬ðan Yanliang 630 Hospital, Xi¬ðan 710089, China, 3Scientific Research Center, Xi¬ðan Medical College, Xi¬ðan 710068, China, 4Economical Department, Engineering College of Armed Police Force, Xi¬ðan 710086, China, 5Center for Biotechnology, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To investigate the effect of the kernel of zanthoxylum seed oil (KZSO) on experimental hyperlipidemia in rats and to probe into the mechanism of preventive and therapeutical effect of KZSO. METHODS: Thirty healthy SD rats were randomly divided into 3 groups, including control group, hyperlipidemia model group and KZSO group. Control group was fed ordinary forage; model group was fed highª²lipid forage; KZSO group was administrated intragastrically KZSO besides highª²lipid forage. Blood samples were obtained by cutting necks after 10ª²week feeding. The levels of blood lipids and the hemorheological parameters were determined, and the activities of superoxide dismutase (SOD) and catalase (CAT), the content of malondialdehyde (MDA) and the restraining ability to hydroxyl free radical (RAHFR) in the liver tissues were measured. RESULTS: Compared with the model group, cholesterol, triglyceride, high blood viscosity ......