脑缺血;缺血预处理；生长相关蛋白43；海马；Wistar大鼠

新生鼠脑缺血预处理后海马CA1区GAP43的表达

http://www.100md.com 《第四军医大学学报》 2000年第5期

脑缺血;缺血预处理；生长相关蛋白43；海马；Wistar大鼠；新生,,脑缺血;缺血预处理；生长相关蛋白43；海马；Wistar大鼠；新生,【关键词】脑缺血;缺血预处理；生长相关蛋白43；海马；Wistar大鼠；新生,0引言,1材料和方法,2结

     Expression and significance of GAP43 in hippocampal CA1 region after cerebral ischemic preconditioning in neonatal rats

    PENG HongJun1, CAO YunTao1, LIU HuaQing2

    1Department of Neonatology, 2Department of Pathology, Affiliated Hospital, Zunyi Medical College, Zunyi 563003, China

    【Abstract】 AIM： To investigate the expression and significance of growthassociated protein43 (GAP43) in hippocampal CA1 region of 7dayold Wistar rats with cerebral ischemic preconditioning. METHODS： Cerebral ischemia in 7dayold Wistar rats was induced by occluding right common carotid artery for 45 min. The Wistar rats were randomly divided into shamoperation group (A), ischemiareperfusion group (B) and ischemic preconditioning group (C). In group C transient cerebral ischemia for 8 min was preformed before the serious cerebral ischemia (for 45 min) after 24 h interval. The pathological changes in the brain were observed by optical microscope, and immunohistochemistry and computer image analysis system were used to detect the expression of GAP43. RESULTS： No brain damage was found in group A ......

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