Theeffectsofvascularendothelialgrowth factor on dendritic cells in esophageal tumor tissue

    YANG Wenª²feng1, LI Daoª²tang1, LI Jing1, CHEN Xuª²xia, WAGN Shanª²zheng2

    1Thoracic Surgery Department of Shandong Cancer Hospital, Jinan 250117; 2Thoracic Surgery Department of Qilu Hospital of Shang dong University, Jinan 250012, China

    \[Abstract\] AIM: To investigate the relationship between vascular endothelial growth factor (VEGF) and S100 protein positive dendritic cell (DC) in esophagelal tumor tissue. METHODS: VEGF and S100 protein in 94 patients with esophageal carcinoma were detected by HRP Labelled streptavidin biotin(LSAB) immunohistochemical method. RESULTS: Postive rate of VEGF in esophageal tumor tissues was 74.46%(70/94); and the later the clinical stage and the lower the differentiation level was the more VEGF was(r=0.864, 0.803, respectively; P<0.05); while the later the clinical stage and the lower the differentiation level was, the less number of S100+DCs existed (r=-0.763, -0.908, respectively; P<0.05). Furthermore, there was a reverse correlation between the expression of VEGF and S100+ DC (r=-0.817, P<0.05). CONCLUSION: There may be a reverse relationship between the expression of VEGF and S100+ DC in esophageal tumor tissue, VEGF could decrease the number of S100+ DC and impair the immunological function of the body. ......