肥胖；肥胖抵抗；营养素吸收_

饮食诱导肥胖和肥胖抵抗大鼠胃肠动力学研究

http://www.100md.com 《中国公共卫生》 2007年第4期

肥胖；肥胖抵抗；营养素吸收,,肥胖；肥胖抵抗；营养素吸收,材料与方法,2结果,3讨论,参考文献

     摘要：目的探讨高脂饮食诱导肥胖易感(OP)大鼠和肥胖抵抗(OR)大鼠胃肠动力和营养素吸收差异，从胃肠的角度揭示肥胖和肥胖抵抗发生的原因。方法高脂饲料喂饲健康雄性SD大鼠8周，筛选出OP大鼠和OR大鼠。实验结束后，连续进行3d代谢实验，并收集大鼠的粪便和尿液，分别测定其营养素含量，并计算出肥胖和肥胖抵抗大鼠的营养素消化吸收量。采用酚红灌胃法测定各组大鼠胃排空率，采用墨汁推进方法测定小肠推进功能。结果 OP大鼠蛋白质和脂肪的摄入量与吸收量显著高于OR大鼠。OP大鼠和OR大鼠胃排空率比较差异无统计学意义，OP大鼠小肠推进率显著高于OR大鼠。结论在高脂饮食诱导下，胃肠动力差异以及营养素摄入和吸收的差异可能是导致肥胖和肥胖抵抗的原因之一。

    关键词：肥胖；肥胖抵抗；营养素吸收

    Study on gastrointestinal function in obesity prone rats and obesity resistant rats induced by diet

    MA Weiwei,WANG Shuran,LIN Weiming,et al.

    Department of Nutrition and Food Hygiene,College of Public Health,Harbin Medical University(Harbin 150081,China)

    Abstract： Objective To explore the differences of nutrients digested and absorptive as well as gastric empting,and intestinal transit in obesity prone (OP) rats and obesity resistant (OR) rats induced by highfat diet.Methods Male SpragueDawley(SD) rats were divided into OP rats and OR rats fed with high fat diet for 8 weeks.Then a threeday metabolism experiment was carried,and feces and urine were collected to measure the fat and protein.Phenol red administration was used to measure the rate of gastric empting and ink administration was used to measure the rate of intestinal transit.Results Obesity prone (OP) rats used more protein and fat than obesity resistant (OR) rats.The gastric empting rate had no significant difference in obesity prone (OP) rats and obesity resistant (OR) rats.The rate of intestinal transit in obesity prone (OP) rats was higher than that in obesity resistant (OR) rats.Conclusion With the high fat diet,one of the reasons that result in obesity prone (OP) rats and obesity resistant (OR) rats is the difference of nutrients digested and absorptive and gastrointestinal motor. ......

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