番茄红素对急性肺损伤大鼠肺泡巨噬细胞影响
番茄红素;急性肺损伤;肺泡巨噬细胞;吞噬功能,,番茄红素;急性肺损伤;肺泡巨噬细胞;吞噬功能,1材料与方法,2结果,3讨论,参考文献
摘要: 目的 观察番茄红素对急性肺损伤大鼠肺泡巨噬细胞吞噬功能的影响。方法 以05,10,30mg/(kg·bw)的番茄红素连续给雄性Wistar大鼠灌胃30d,用脂多糖制造大鼠急性肺损伤模型,分别在1,4,6h后支气管肺泡灌洗,检测肺泡巨噬细胞吞噬功能、细胞计数以及肺相对重等指标。结果 在各剂量番茄红素作用下,肺泡巨噬细胞吞噬功能明显增强,与模型组相比,注射脂多糖1h后,喂饲番茄红素组吞噬功能增强,增强率分别为112%,279%,381%;4h后,增强率分别为59%,44%,170%;6h后,增强率分别为166%,152%和219%。番茄红素3个剂量组之间呈剂量反应关系(P<005)。结论 番茄红素在05,10,30mg/(kg·bw)剂量下能增强肺泡巨噬细胞的吞噬功能。关键词: 番茄红素;急性肺损伤;肺泡巨噬细胞;吞噬功能
Effect of lycopene on function of pulmonary alveolar macrophages of rat's acute lung injury
DONG Danjun,LIN Xiaoming.
Department of Nutrition and Food Hygiene,School of Public Health,Peking University(Beijing 100083,China)
Abstract: Objective To study the effect of lycopene on the function of pulmonary alveolar macrophages(PAMs)of rat's acute lung injury(ALI).Methods Male rats were gavaged continuously by lycopene with 05,10,30mg/kg for 30 days;Lipopolysaccharide was used to make the model of ALI rats.After 1hour,4 and 6hours,bronchoalveolar lavage was done ......
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