摘要：目的：观察大鼠口服通脉活血灵胶囊后，其效能成分大黄酚在大鼠体内的药动学过程。方法：大鼠单次灌服通脉活血灵胶囊，用反相高效液相法测定不同时间的血药浓度，采用DAS2.0药动学软件拟合处理该药的药动学参数。结果：通脉活血灵胶囊中大黄酚在大鼠体内的药动学参数：T1/2α，T1/2β，AUC(o-∞)，K10，K12，K21，Tmax，Cmax分别为：1.054h，4.197h，2479.555 mg/L，0.077 1/h，0.222 1/h，0.407 1/h，0.5h，230.58 mg/L。结论：单次灌服通脉活血灵胶囊后，大黄酚在大鼠体内的药动学过程符合开放型二室模型，吸收快，消除慢，同服用单味大黄后大黄酚在家兔体内的药动学过程有一定的差异。

    关键词： 通脉活血灵胶囊; 大黄酚; 血药浓度; HPLC

    Determination of chrysophanol from Tongmaihuoxueling Capsules in rat’s plasma and study on its pharmacokinetics

    LI Lan-fang, ZHANG Qin-zeng, XIE Li-jun, et al

    (Hebei Provincial Academy of Medical Science, Hebei Shijiazhuang 050021)

    Abstract: Objective: To study the pharmacokinetics of chrysophanol in rats after ig administration of Tongmaihuoxueling capsules(TC). Methods: The concentrations of chrysophanol in plasma were determined by RP-HPLC method after single ig administration of TC. The parameters of pharmacokinetics were computed by DAS 2.0 program. Results: The pharmacokinetic parameters of chrysophanol from TC in rats were as follows: T1/2α ......