三物白散加味方；_癌化学预防____

三物白散加味方癌化学预防作用实验研究

http://www.100md.com 《时珍国医国药》 2005年第12期

三物白散加味方；,癌化学预防,,三物白散加味方；,癌化学预防,1实验材料,2实验方法,3结果,4讨论,参考文献：

     摘要：目的：观察三物白散加味方癌化学预防作用。方法：进行三物白散加味方抗变、影响rasP21基因表达、抗氧化三项研究。结果：三物白散加味方中、大剂量组有抗变和降低rasP21基因表达作用；小剂量组有抗氧化作用。结论：从初步研究认为，三物白散加味方具有癌化学预防作用。

    关键词：三物白散加味方；癌化学预防

    Experimental Research on Chemical Prevention Effects of Modified Sanwubai Powder

    XU Li, WANG Mingyan, XU Dongqing, ZHOU Chunxiang

    (Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China)

    Abstract：Objective：To observe chemical prevention effects of Modified Sanwubai Powder.Methods：Antimutation functions, gene expression of rasP21 and antioxydizing functions were studied.Results：Modified Sanwubai San in high and moderate dosages had antimutation functions and reducing rasP21 gene expression, low dosage had antioxydizing functions.Conclusion：Modified Sanwubai Powder had the effects of chemical prevention for cancer in preliminary experiments.

    Key words：Modified Sanwubai Powder; Chemical prevention for cancer; Experimental research

    癌化学预防着眼于用药物或食物成分阻断癌变的发生及癌前病变的进展或使其逆转以控制、减少恶性肿瘤的发生，从理论上讲它应当是减少癌的发生最可行的方法。研究证明，癌的发生至少经过三个阶段，即始发(initiation)、促癌(promotion)及演进(progression) ......

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