脑缺血；_雌激素受体α；_葛根素；_雌激素；

葛根素对大鼠局灶性脑缺血后雌激素受体α阳性神经元变化的影响

http://www.100md.com 《时珍国医国药》 2007年第1期

脑缺血；,雌激素受体α；,葛根素；,雌激素；,免疫组织化学,,脑缺血；,雌激素受体α；,葛根素；,雌激素；,免疫组织化学,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的探讨脑缺血损伤后ERα阳性细胞的动态变化及葛根素对其影响。方法制作大脑中动脉阻断模型,使用免疫组化方法观察缺血不同时间ERα免疫阳性神经元的表达。结果在脑缺血后不同时间点,假手术组、雌激素组和葛根素组ERα阳性神经元数量均高于对照组。结论葛根素可以上调脑缺血后ERα免疫阳性神经元的表达,可能通过ERα发挥对脑缺血半暗带神经元的保护作用。

    关键词：脑缺血；雌激素受体α；葛根素；雌激素；免疫组织化学

    The Effect of Puerarin on Estrogen Receptor Alpha Positive Neurons of Rats after Focal Cerebral Ischemia

    SONG Hongshan,HE Keli，WANG Jianmin

    (Department of Anatomy,Jiangxi University of Traditional Chinese Medicine, Nanchang 330004,China)

    Abstract：ObjectiveTo investigate the effect of puerarin on estrogen receptor alpha(ERα)positive neurons of rats after focal cerebral ischemia.MethodsUsing a model of focal cerebral ischemia which was introduced by occluding middle cerebral artery, and then observing the expression of ERα positive neurons at different ischemic time and the change after giving estradiol benzoate or puerarin with the methods of immunohistochemistry. ResultsIn sham OVX group, estradiol benzoate treatment group and puerarin treatment group, ERα positive neuron expression was higher than that in the OVX control group at different ischemic time. ConclusionPuerarin can increase the expression of ERα positive neurons at various times after middle cerebral artery occlusion and protect nerve cells of ischaemic penumbra. ......

百拇医药网 http://www.100md.com/html/DirDu/2007/04/28/42/93/16.htm

您现在查看是摘要页，全文长 10193 字符。