肿瘤；抑郁；焦虑；帕罗西汀_

肿瘤患者伴发焦虑抑郁障碍临床观察

http://www.100md.com 《临床心身疾病杂志》 2007年第1期

肿瘤；抑郁；焦虑；帕罗西汀,,肿瘤；抑郁；焦虑；帕罗西汀,1对象与方法,2结果,3讨论,参考文献

     【摘要】目的探讨帕罗西汀治疗肿瘤患者伴发焦虑抑郁障碍的疗效及安全性。方法将筛选出的52例肿瘤伴发抑郁焦虑障碍患者随机分为研究组25例，对照组27例。两组均给予正规的抗肿瘤治疗，研究组联合帕罗西汀20 mg·d-1治疗，对照组不进行抗焦虑抑郁治疗，两组均观察8w。采用抑郁自评量表、焦虑自评量表评定临床疗效。结果 63.41%的肿瘤患者伴有不同程度的抑郁焦虑症状，治疗4 w,8 w末研究组抑郁自评量表、焦虑自评量表评分较治疗前显著下降(P<0.01)，同期评分均显著低于对照组(P<0.01)。结论帕罗西汀治疗肿瘤伴发焦虑抑郁障碍疗效显著，安全性高，依从性好，可显著改善患者的生活质量。

    【关键词】肿瘤；抑郁；焦虑；帕罗西汀

    Features of tumor patients accompanying anxietydepression and clinical curative effect

    Zhang Baozhong

    (Huantai County People’s Hospital,256400,Shandong,China)

    【Abstract】 Objective To explore the curative effect and safety of paroxetine in tumor patients with anxietydepression. Methods 52 selected tumor patients accompanying anxietydepression were randomly divided into research group(n=25) receiving normal antineoplaston plus paroxetine 20mg/d and control group(n=27) doing single antineoplaston for 8 weeks. Curative effects were assessed with the SDS and SAS. Results 63.41% of the patients accompanied anxiousdepressive symptoms, at the ends of 4th and 8th week scores of the SDS and SAS decreased significantly compared with pretreatment(P<0.01) and were obviously lower in the research group than in the control group(P<0.01). Conclusion Paroxetine has notable curative effect, higher safety and better compliance in tumor patients accompanying anxietydepression, and could improve patient’s quality of life. ......

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