摘要:目的：比较药物洗脱支架与普通支架植入前后冠心病患者血超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、P选择素(P-selectin)、可溶性细胞间粘附分子(sICAM-1)的变化，探讨其意义。方法：选择有支架植入指征的冠心病患者66例，随机分为药物支架组和普通支架组，30例置入Cypher(Cypher支架组)，36例置入普通Bxsonic支架(普通支架组)。分别于手术前，术后即刻，术后6h、术后24h、7d取肘静脉血, 采用ELISA法检测IL-6、P选择素、slCAM-1 、hs-CRP。结果：Cypher支架组与普通支架组比较P选择素、IL-6、sICAM-1、 hs-CRP水平在扩张前、术后即刻没有显著性差异(P>0.05)而术后6h、24h、7d时Cypher支架与普通支架比较测定值低且差异有显著性(P<0.05～0.01)。结论:Cypher药物洗脱支架对冠心病患者介入术后血炎症因子的产生有抑制作用，可能抑制介入术后的炎症反应是其抗再狭窄的机制之一。

    关键词: 药物洗脱支架； 超敏C反应蛋白质； 白细胞介素-6

    The Effects of Drug Eluting Stents on Level of Inflammatory Factors in Patients with CHD after Angioplasty

    WANG Lin-guang, et al

    (Xuzhou Cardiovascular Disease Institute, Jiangsu Xuzhou 221009, China)

    Abstract： Objective： To compare the effects of drug eluting stent versus common stent on the levels of serum high sensitive C-reactive protein(hs-CRP), interleukin-6(IL-6),plasma P-selectin and soluble intercellular adhesion molecule-I (sICAM-1) in patients with coronary heart disease before and after angioplasty. Method： 66 patients had been done coronary angiograph and divided randomizely into drug-eluting stents implantment group(30 cases of Cypher stent implantment) and common stents implantment group(36 cases of common stent implantment).Peripheral venous blood samples were taken before, immediately,at 6,24 hours, seven days after angioplasty. The levels of hs-CRP , sICAM-1, IL-6 and P-selectin were analyzed by enzyme linked immunosorbent assay(ELISA). Result： There were no significant difference between the two groups at before and immediatety on levels of hs-CRP , sICAM-1, IL-6 and P-selectin. At 6 hours, 24 hours and seven days after angioplasty, the levels of hs-CRP , sICAM-1, IL-6 and P-selectin were significantly lower in Cypher group than those in common stent group. Conclusion： The Cypher drug-eluting stents can reduce the levels of inflammatory factors after angioplasty. The results suggested that suppressing inflammatory factors maybe one of reasons for lowing restenosis. ......