【摘要】 IFN的产生与dsRNA之间的相关研究已获得显著进展，目前已发现细胞内有两种酶(PKR，25AS)与干扰素的产生密切相关，而且在干扰素诱生的过程中，dsRNA链上的多聚肌苷胞苷酸(聚肌胞)Poly(I:C)能被双链RNA依赖蛋白激酶(PKR)特意性激活。DsRNA与干扰素间的相关性还表现在许多细胞调节因子和效应因子上，例如IRFs，Mx蛋白，Toll-Like受体的mAb和一些细胞因子，同时，dsRNA能通过IFN的诱生来激发细胞产生凋亡现象，若两者之间的相关性通过细胞转染技术来实现，则可得到进一步的探讨和研究。

    【关键词】 干扰素；dsRNA；转染，凋亡

    Correlation and transfection applying betneen dsRNA and interferon

    WANG Hai-qi.Biology Engineering College of Jimei University,Xiamen 361021,China

    【Abstract】 The distinct advance have been formed about the correlation rsearch between dsRNA and interferon(IFN), recently it’s found that there are two enzymes in the cell tightly correlating with the production of IFN. And during the production of IFN induction, the polyinosinic polycytidylic Acid, poly(I:C)in the dsRNA chain could be specific activated by double-stranded RNA-dependent protein kinase(PKR).In addition,many cellar regulator and effector also expressed the correlation between IFN and dsRNA,such as interferon regulatory factors(IRFs), mx protein,the mAb of toll-like receptor, and some cytokine.Simultaneously,dsRNA could activate the cell programmed death through the induction of IFN, if the correlation could be realized and communicated by the technology of cell transfection, it would be exploited and researched more deeply and completely. ......