β环糊精；_挥发油；_正交实验____

维心颗粒中挥发油β环糊精包合物的制备研究

http://www.100md.com 《时珍国医国药》 2005年第12期

β环糊精；,挥发油；,正交实验,,β环糊精；,挥发油；,正交实验,1材料和仪器,2方法与结果,3结果与讨论,参考文献：

     摘要：目的：研究维心颗粒中挥发油β环糊精包合物的制备方法并验证包合物的形成。方法：通过正交实验，考察温度、投料比、包合时间等因素对包合的影响，以包合率及收率的综合评分为指标，优选最佳工艺。采用UV和GC法对包合物进行验证。结果与结论：最佳工艺为：25℃，β环糊精与挥发油的比例为4∶0.6,包合30 min。包合前后的紫外图谱出现了明显变化，说明新的物相已经形成；通过GC验证，包合前后的化学组成没有明显变化。

    关键词：β环糊精；挥发油；正交实验

    Study on Inclusion Compound of Volatile Oil βcyclodextrin in Weixin Granule

    HUANG Yi, XU Fang, YAN Ming, CHU Zhongjun, MU Balake

    (Xinjiang Institute of Materia Medica , Urumqi 830002， China ； Xinjiang Medical University, Urumqi 830000, China)

    Abstract:Objective:To study the preparation method of the inclusion compound of volatile oil βcyclodextrin in WeiXin Granule and test the formation of inclusion compound.Methods:The optimum process was studied by orthogonal design with score as markers. The inclusion compound was tested by UV and GC.Results & Conclusion:The optimum process : room temperature, 30 min, 4∶0.6 (βCD: volatile oil) . The different UV spectrum after being included by βCD showed that a new physical phase had formed between oil and βCD. The same GC spectrum showed that the chemical composition of oil did not change obviously after being included by βCD . ......

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