[摘要] 目的 研究KAI-1在不同分期、分级、预后和年龄组肾细胞癌中的表达，分析其表达的意义。方法 随访1991～2000年入院治疗并留取病理标本的肾癌病例预后。根据临床分期、细胞分级、年龄、T1-3aN0M0病例是否术后转移分别将肾癌病例分组，应用免疫组织化学方法检测肾癌标本KAI-1表达，卡方检验分析KAI-1表达的差异。结果 30～70岁每十年龄段KAI-1阴性表达率为34.4%～47.8%，比较低表达率χ2值为0.54～1.19，P均>0.05，过表达率χ2值为0.84～1.84，P均>0.05。肾癌TNMⅠ～Ⅳ期KAI-1阴性表达率为34.2%、25.2%、54.4%和80.0%，Ⅰ、Ⅲ、Ⅳ期间过表达比较P<0.05。Fuhrman分级Ⅰ～Ⅲ级KAI-1阴性表达率为33.0%、47.8%、81.4%，Ⅱ和Ⅲ、Ⅰ和Ⅲ级比较χ2值分别为9.11、27.24，P均<0.01。T1-3aN0M0术后转移组24例和未转移组194例KAI-1阴性表达率为79.2%、9.8%；两组低表达率比较χ2值＝64.49，P<0.01；过表达χ2值＝0.02，P>0.05。结论 转移抑制基因KAI-1在肾癌中的表达与年龄因素无关。KAI-1低表达或表达缺失率在Ⅲ期、Ⅳ期和Fuhrman Ⅲ级肾癌中最高。KAI-1基因缺失可能参与了T1-3aN0M0肾癌术后转移的发生，检测KAI-1表达具有临床预后指导价值。

    [关键词] 肾细胞；癌；KAI-1；转移抑制基因

    Expression of metastases suppressor gene KAI-1 on renal cell carcinoma and its significance

    ZHANG Lu-fang，PAN Dong-liang，PENG Xue-ye,et al.Department of Urology，Shandong People’s Hospital，Weifang 261042，China

    [Abstract] Objective To study the expression of metastases suppressor gene KAI-1 on renal cell carcinoma(RCC) and analyze its significance.Methods The patients with RCC undergoing surgical operations from 1991 to 2000 were followed up and their prognoses were written down.Then these patients were divided into different groups according to their clinical stages ......