【摘要】 目的 了解尿毒症患者神经精神症状和情感障碍的发生情况及以血液净化治疗为主的综合治疗对其的改善情况。方法 79例尿毒症患者按血肌酐值分为n1、n2组。采用平行对照研究方法，对尿毒症患者治疗前后的神经精神症状进行评估，并进行SAS和SDS量表测定。结果 n1组尿毒症患者神经、精神症状的出现频数分别10.6%、27.7%，焦虑和抑郁发生率分别是51.1%、68.1%，治疗后其神经、精神症状的出现频数以及焦虑和抑郁发生率分别是0.7%、8.5%、23.4%和34.0%；n2组尿毒症患者神经、精神症状的出现频数分别74.7%、59.8%，焦虑和抑郁发生率分别是69.0%、82.8%，治疗后其神经、精神症状的出现频数以及焦虑和抑郁发生率分别是19.5%、28.7%、41.4%和51.7%。结论 尿毒症患者血肌酐值越高，其神经精神症状越明显，情感障碍的发生率越高；经过有效合理的治疗尿毒症患者的神经精神症状和情感障碍的发生情况都可以得到改善。

    【关键词】 尿毒症；尿毒症脑病；焦虑；抑郁

    Clinical study of pre- and postreatment of nervous system symptomin patients with uremia

    BI Wei-hong, WANG Ting, TAO Ming-de. Department of Nephrology, Third Hospital of Mianyang,Sichuan 621000,China

    【Abstract】 Objective To investigate the prevalence of nervous and psychic system symptom, anxiety and depression in patients with uremiaand the efficacy of blood purification for them. Methods A parallelcomparison controlled clinical study was conducted for evaluating the prevalence of nervous and psychic system symptompre- and postreatment. Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) were also administered to them. Results The prevalence of nervous and psychic system symptom, anxiety and depression in n1patients were 10.6%, 27.7%, 51.1%and 68.1% respectively, the prevalence were 74.7%, 59.8%,69.0%and 82.8% in n2patients. After treatmentthe prevalence in n1and n2 patients were 0.7%, 8.5%, 23.4%, 34.0% and 19.5%, 28.7%, 41.4% and 51.7% respectively.Conclusion The prevalence of nervous and psychic system symptom, anxiety and depression are significantly higher in uremic patients with a various degree of CRF. After reasonableand effective treatment, the prevalence of nervous and psychic system symptoms, anxiety and depression in patients with uremiawas reducedevidently. ......