运动对慢性心理应激大鼠影响
慢性心理应激；运动；皮质醇；白细胞介素-2；白细胞介素-6,,慢性心理应激；运动；皮质醇；白细胞介素-2；白细胞介素-6,1材料与方法,2结果,3讨论,参考文献
摘要： 目的 研究运动对慢性心理应激大鼠血清皮质醇、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)的影响。方法 建立慢性心理应激模型，进行6周游泳训练：测定各组大鼠血清皮质醇、IL-2、IL-6的含量。结果 (1)应激组大鼠血清皮质醇含量显著高于对照组(P<001)，血清IL-2、IL-6水平显著低于对照组(P<001);(2)30min运动组血清IL-2水平显著高于对照组(P<001)，60min运动组血清IL-2、IL-6水平均显著高于对照组(P<001)，血清皮质醇含量显著低于对照组(P<005);(3)应激+30min运动组、应激+60min运动组血清皮质醇含量显著低于应激组(P<001)，IL-2和IL-6水平显著高于应激组(P<001)。结论 慢性心理应激引起大鼠下丘脑-垂体-肾上腺皮质(HPA)轴释放过量皮质醇，使免疫功能受到抑制；适量运动能够调节HPA轴适应性，降低皮质醇的过量释放，维护免疫功能稳定。关键词： 慢性心理应激；运动；皮质醇；白细胞介素-2；白细胞介素-6
Effects of physical exercise on chronic psychological stress in rats
ZHANG Yine,SONG Hui,YANG Huifang,et al.
Department of Preventive Medicine,Ningxia Medical College(Yinchuan 750004,China)
Abstract： Objective To investigate the effect of exercise on the cortisol,interleukin-2 and interleukin-6 in rats of chronic psychological stress.Methods To construct chronic psychological stress model and carry out swim for 6 weeks in rats.The contents of cortisol,IL-2 and IL-6 were detected.Results (1)The plasma IL-2 and IL-6 levels in chronic psychological stress group was significantly lower than that in control group(P<0.01),while their cortisol level was significantly higher than that in control group(P<0.01).(2) The plasma IL-2 levels in 30min exercise group were significantly higher than that in control group(P<0.01);the plasma IL-2 and IL-6 levels in 60min exercise group were significantly higher than that in control group(P<0.01) while their cortisol level was significantly lower than that in control group(P<0.05);(3)The plasma IL-2 and IL-6 levels in both stress plus 30min exercise group and stress plus 60min exercise group were significantly higher than that in stress group(P<0.01),while their cortisol level was signficantly lower than that in stress group(P<0.01).Conclusion Chronic psychological stress depressed the immune function of rats,and exercise could effectively protect the immune system;Exercise could regulate the adaptation of hypothalamic-pituitary-adrenocortical(HPA) axle and the excretion of the hormone,which could be the possible mechanism that maintained the stability of the immune. ......
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