【摘要】 目的 探讨阿立哌唑治疗儿童精神分裂症的疗效及安全性。 方法 将50例儿童精神分裂症患者随机分为两组各25例，研究组给予阿立哌唑治疗，对照组给予利培酮治疗，观察8 w。于治疗前及治疗1 w、2 w、4 w、6 w、8w末采用潘氏量表评定临床疗效，副反应量表及锥体外系反应量表评定不良反应。 结果 治疗8 w末研究组总有效率84.0%，对照组92.0%，两组总体疗效相当(χ2=0.271，P>0.05)。潘氏量表评分两组治疗2w末起均较治疗前有极显著性下降(P均<0.01)；研究组治疗1 w末潘氏量表P分较对照组下降显著(P<0.05)。研究组肌强直、震颤、静坐不能、体重增加不良反应发生率显著低于对照组(P<0.05)。 结论 阿立哌唑治疗儿童精神分裂症疗效与利培酮相当，缓解阳性症状更快，安全性高，依从性好。

    【关键词】 阿立哌唑；利培酮；儿童精神分裂症；潘氏量表；副反应量表

    A control study of aripiprazole in the treatment of childhood schizophrenia

    Zhang Yongfu, Zhang Haifeng, Gu Wei

    (Han zhong Mental Hospital，723003，Shanxi, China)

    【Abstract】 Objective To explore the curative effect and safety of aripirazole in the treatment of childhood schizophrenia.Methods 50 patients with childhood schizophrenia were randomly divided into research(took aripirazole, n=25) and control group( did risperidone, n=25) for 8 weeks. Before treatment and at the ends of the 1st, 2nd, 4th, 6th and 8th week, curative effects were assessed with the Positive and Negative Syndrome Scale(PANSS) and adverse effects with the Treatment Emergent Symptom Scale and the Scale for Extrapyramidal Side Effects(ESRS), respectively. Results At the end of 8th week, total effective rates were 87.5% in the research and 92% in the control group respectively, the total effectiveness of the 2 groups was equivalent(χ2 = 0.271,P>0.05).Since the end of the 2nd week, the PANSS scores of both groups decreased very significantly compared with pretreatment(both P<0.01); at the end the 1st week, P score of the PANSS in the research group decreased more significantly than in the control group(P<0.05). Conclusion Aripiprazo1e has therapeutic equivalence to risperidone in childhood schizophrenia, relieves positive symptoms faster and has higher safety and better compliance. ...... 如果您在使用手机等流览时无法查看或下载全文，可能是被搜索引擎失真“转码”，请点击屏幕最下方的“电脑版”或“原网页”访问。


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