姜黄素类化合物的分离及其抗肝癌和子宫内膜癌的研究
姜黄素类化合物；,肝癌；,子宫内膜癌,,姜黄素类化合物；,肝癌；,子宫内膜癌,1仪器与材料,2方法与结果,3讨论,参考文献：
摘要：目的从中药姜黄提取3种姜黄素类化合物并对它们进行抗肝癌细胞和子宫内膜癌作用研究。方法采用柱层析法从姜黄提取物中分离出3种姜黄素类化合物，用MTT法测定其抗肝癌细胞和子宫内膜癌作用。结果3种姜黄素化合物分别鉴定为姜黄素﹑脱甲氧基姜黄素和双脱甲氧基姜黄素。0.01 mg/ml双脱甲氧基姜黄素， 0.01 mg/ml和0.001 mg/ml脱甲氧基姜黄素能明显抑制肝癌细胞的生长；0.01 mg/ml和0.001 mg/ml双脱甲氧基姜黄素， 0.01 mg/ml脱甲氧基姜黄素, 0.01 mg/ml 和 0.001 mg/ml姜黄素能明显抑制子宫内膜癌细胞的生长。结论 一定浓度的姜黄素化合物能明显抑制肝癌和子宫内膜癌细胞的生长。关键词：姜黄素类化合物； 肝癌； 子宫内膜癌
Isolation of Curcuminoids and its Effects on Liver Cancer and Endometrial Carcinoma
PENG Bingxian, ZHOU Xin, SHI Jingshan
(College of Chemistry and Chemical Engineering , Jiangxi Normal University, Nanchang 330022, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002 ,China; Zunyi Medical College, Zunyi 563003, China)
Abstract：ObjectiveTo extract three curcuminoids from Curcuma langa and study there effects on liver cancer and endometrial carcinoma.MethodsThree curouminoids were got from the extract of Curcuma langa with column chromatography and their effects on liver cancer and endometrial carcinoma were determined by MTT. ResultsThree curcuminoids were identified as curcumin, demethoxycurcumin and bisdemethoxycurcumin. It showed that 0.01mg/ml curcumin ......
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