通脉降脂颗粒；_姜黄素；_大黄酸；_大黄酚；

通脉降脂颗粒的质量标准研究

http://www.100md.com 《时珍国医国药》 2007年第3期

通脉降脂颗粒；,姜黄素；,大黄酸；,大黄酚；,大黄素；,高效液相色谱法,,通脉降脂颗粒；,姜黄素；,大黄酸；,大黄酚；,大黄素；,高效液相色谱法,1器材,2方法与结果,3讨论,参考文献：

     摘要：目的建立通脉降脂颗粒剂的质量标准。方法采用薄层层析(TLC)法对通脉降脂颗粒中的姜黄素、大黄酸、大黄酚、大黄素、芦荟大黄素进行定性鉴别，高效液相色谱(HPLC)法定量测定姜黄素、大黄酸、大黄酚、大黄素的含量。结果用C18柱，流动相为甲醇水乙酸(77∶22∶1)，检测波长为428nm，测定结果的线性关系良好。姜黄素、大黄酸、大黄酚、大黄素的平均回收率分别为97.75%，96.65%，97.79%，97.17% 。结论采用高效液相色谱法对通脉降脂颗粒进行质量控制，方法简便，准确，重复性好。

    关键词：通脉降脂颗粒；姜黄素；大黄酸；大黄酚；大黄素；高效液相色谱法

    Study on Quality Standard for Tongmai Jiangzhi Granule

    WU Zhengang，PAN Haiyu，HAN Gang*，LI Yun，WANG Chao

    (North China Coal Medical College , Tangshan 063000,China)

    Abstract：ObjectiveThe quality standard of Tongmai Jiangzhi Granule has been established. MethodsTLC was used to identify curcumin, rhein, emodin, chrysophanol, aloe-emodin. HPLC was used to determine the contents of curcumin, rhein, emodin, and chrysophanol. ResultsThe linear relation was excellent for determination with C18 column methanol-water-acetic acid (77:22:1) as mobile phase. The average recoveries of curcumin, rhein, emodin, chrysophanol were 97.75%,96.65%,97.79% and 97.17%, respectively. ConclusionThe methods are available with a good reproducibility and can be used to control the quality of Tongmai Jiangzhi Granule. ......

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