三参胶囊；_质量标准；_薄层色谱；_高效液相色谱_

三参胶囊的质量标准研究

http://www.100md.com 《时珍国医国药》 2007年第3期

三参胶囊；,质量标准；,薄层色谱；,高效液相色谱,,三参胶囊；,质量标准；,薄层色谱；,高效液相色谱,1仪器与试药,2方法与结果,3讨论,参考文献：

     摘要：目的建立三参胶囊的质量标准。方法采用薄层色谱法对丹参、人参、制首乌进行了定性鉴别，采用反相高效液相色谱(RP-HPLC)法测定了胶囊中丹参素钠的含量，采用Shimpack VP-ODS C18柱(5 μm，150 mm×4.6 mm)；检测波长280 nm；流动相：0.5%冰醋酸-甲醇(94∶6)；流速：1.0 ml·min-1；柱温：30℃。结果此法线性范围0.110 9～1.663 5μg，r=0.999 9；丹参素钠的平均回收率为98.82%(RSD=1.45%，n=5)。结论该方法稳定、可靠，可作为该制剂的质量控制方法。

    关键词：三参胶囊；质量标准；薄层色谱；高效液相色谱

    The Study on the Quality Standard for Sanshen Capsule

    LAN Yan， CHEN Wenwen，LUO Cheng，HUANG Qinwan，WU Chunjie*

    (Chengdu University of Traditional Chinese Medicine, Chengdu 610072,China)

    Abstract：Objective To develop a quality standard for Sanshen capsule. MethodsTLC was used to identify the ingredients such as Danshen Root Ginseng Root and Tuber Fleeceflower Root respectively . Meanwhile, the content of Danshensu in Sanshen capsule was determined by RPHPLC with Shim-pack VP-ODS C18(5 μm，150 mm×4.6mm) .The detection wavelength was 280 nm；0.5%Acetic acid-Methanol(94∶6)was used as mobile phase, the rate of 1.0 ml·min-1and the column temperature was at 30℃.ResultsThe method was linear within the range of 0.110 9～1.663 5 μg,(r=0.999 9). The average recovery of Danshensu was 98.82%,(RSD＝1.45% ......

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