变应性鼻炎；_鼻敏水滴鼻剂____

鼻敏水治疗变应性鼻炎大鼠的实验研究

http://www.100md.com 《时珍国医国药》 2007年第1期

变应性鼻炎；,鼻敏水滴鼻剂,,变应性鼻炎；,鼻敏水滴鼻剂,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的探讨鼻敏水滴鼻剂治疗变应性鼻炎药效。方法以卵清白蛋白致敏大鼠制做I型变态反应动物模型，随机分为3组:模型对照组、鼻敏水组、药物对照组，并设正常对照组，分别观察各组大鼠行为学表现及测定其鼻黏膜组胺含量、鼻分泌物和血清嗜酸性粒细胞、血清总IgE水平。结果行为学积分，给药后鼻敏水组、药物对照组行为学积分明显低于模型对照组(P<0.01)，鼻敏水组积分低于药物对照组(P<0.01)；鼻敏水组和药物对照组鼻黏膜含量、鼻分泌物嗜酸性粒细胞明显低于模型对照组(P<0.01)，鼻敏水组和药物对照组比较有显著性差异(P<0.01)；鼻敏水组和药物对照组血清嗜酸性粒细胞记数、总IgE水平明显低于模型对照组(P<0.01)，鼻敏水组和药物对照组比较无统计学意义(P>0.05)。结论鼻敏水滴鼻剂能降低实验性大鼠鼻黏膜组胺含量，抑制或降低其血清总IgE水平及嗜酸性粒细胞记数，提示鼻敏水滴鼻剂对变应性鼻炎具有治疗作用。

    关键词：变应性鼻炎；鼻敏水滴鼻剂

    Experimental Research on the Treatment with BiMinShui on Allergic Rhinitis of Rats

    HUANG Zhuoyan, ZHANG Mian, WEI Zizhang, FANG Yanfei

    (First Affiliated Hospital of Guangxi College of TCM,Nanning 530023,China)

    Abstract：ObjectiveTo investigate the medical effect of BiMinShui nose drops on the treatment of allergic rhinitis. MethodsTo make typeⅠallergological rat models allergized by ovalbumin, and divide the models into three groups at random:the group of control, the group of BiMinShui and the group of drug control.Besides, to establish a group of nonmedical models. To observe the ethological performance of rats and examine the contents of histamine in nasal nucous coat, nasal secretions; oxyphilic granular leukocytes and total IgE values in blood serum.ResultsThe posttreatment ethological integration in the group of BiMinShui and the group of drug control was significantly lower than that in the group of control(P<0.01).Integration in the group of BiMinShui was lower than that in the group of drug control(P<0.01).The contents of histamine in nasal mucous coat, nasal secretions and oxyphilic granular leukocytes in the group BiMinShui were obviously lower than those in the control group(P<0.01).The distinction between the group of BiMinShui and the group of drug control was significant(P<0.01).The counting of oxyphilic granular leukocytes and total IgE values in the group of BiMinShui and the group of drug control were evidently lower than those in the group of control(P<0.01),but the distinction between the group of BiMinShui and the group of drug control was of no statistical significance(P>0.05).ConclusionBiminshui nose drops can reduce the contents of histamine in nasal nucous coat of experimental rats, constrict or decline the total IgE values in blood serum and the counting of oxyphilic granular leukocytes. BiMinShui nose drops is effective in treating allergic rhinitis. ......

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