[摘要] 目的 探讨谷氨酰胺联合肠内营养对动物模型结肠黏膜凋亡的影响。方法 将大鼠随机分为3组，即正常组，模型组、谷氨酰胺组21天两个时间点进行观察。结果 谷氨酰胺组Bcl-2的平均灰度值及表达阳性的面积明显大于其他组，Bax基因蛋白平均灰度值及表达阳性的面积明显小于其他组(P<0.05)。结论 谷氨酰胺能抑制结肠黏膜细胞的凋亡，促进结肠的代偿。

    [关键词] 谷氨酰胺；短肠综合征；结肠黏膜；凋亡

    Influence of glutamine to apoptosis of colon mucosa rat of short bowel syndrome model

    LIN Fang-cai，SUN Xin，ZHAO Da-zhong，et al.Department of General Surgery，Beijing Dianli Hospital,Beijing 100073，China

    [Abstract] Objective To detect the influence of glutamine combined with enteral nutrition to apoptosis of rat colon mucosa model.Methods Rats have been divided into 3 groups，that is normal group，model group and glutamine group，which were observed at 21th day.Results Glutamine group Bcl-2 and Bax gene protein’s average gray density and expression planimeter are different significantly with other groups.Conclusion Glutamine group Bcl-2 and Bax gene protein’s average gray density and expression planimeter are significantly with other groups.Glutamine group can prevent apoptosis of colon mucosa enhance compensation of colon mucosa of rats. ......