【摘要】 目的 调查本院下呼吸道感染住院患者克雷伯菌感染的情况及耐药情况，为临床治疗提供参考。方法 回顾分析2003年1月～2006年12月下呼吸道感染住院病人痰、咽拭子培养结果。结果 总共培养阳性标本809例，肺炎克雷伯菌207例，近4年中感染率有下降趋势。耐药性分析：氨苄西林基本耐药，对三代头孢耐药性明显升高，其他几种抗生素敏感性有不同程度升高。结论 肺炎克雷伯菌在下呼吸道细菌感染中感染率有下降趋势，耐药性明显升高，减少抗生素使用能使其耐药性降低，临床用药应策略使用抗生素，并根据药敏适当调整。

    【关键词】 下呼吸道感染； 肺炎克雷伯菌； 培养

    Investigation and analysis on 207 cases of Klebsiella infections in lower respiratory tract

    WANG Xue-fang,SUN Hui-fang.Department of Pediatrics,Wujing Hospital,Shanghai 200241,China

    【Abstract】 Objective To investigate the Klebsiella pneumoniae infections and antibacterial resistance rates in lower respiratory tract infection(LRTI)in patients, for the guidance on the rational usage of antibiotics. Methods Retrospective analysis was conducted on sputum and respiratory secretions cultivation results of LRTI patients who were hospitalized from January 2003 to December 2006.Results LRTI patients were surveyed，807 sputum samples were cultivated positive.207 samples were Klebsiella pneumoniae positive, the positive rate of Klebsiella pneumoniae is descended in four years. The antibacterial resistance rates of Klebsiella pneumoniae, ampicillin almost all resistance, cephalosporins resistance is significantly higher than before.Conclusion The positive rate of Klebsiella pneumoniae is descended in four years. the antibacterial resistance rates of Klebsiella pneumoniae is significantly higher than before. Decrease usage of antibiotic can descend the antibacterial resistance rates of Klebsiella pneumoniae,drug susceptibility test and rational use of antibiotics are important. ......