Therapeutic effect of tetramethylpyª²razine for experimental acute pancreatitis in rats

    WANG Chengª²Guo, MA Qingª²Jiu, LU Jianª²Guo, HE Xianª²Li, WANG Qing, DU Xiª²Lin

    Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi¬ðan 710038, China

    ¡¾Abstract¡¿ AIM: To study the effect of tetramethylpyrazine (TMP) on inflammatory mediators during acute pancreatitis (AP) in rats. METHODS: A total of 96 SD male rats weighing 280-320 g were randomized into 3 groups: control group (n=24), AP group (n=36) and TMP group (n=36). The models of AP in the latter 2 groups were established by the injection of 35 g/L sodium taurocholate ip into the rats. The animals in the 3 groups were killed 3, 6, 12 and 24 h after operation to test the serum levels of plateletª²activating factor (PAF), TNFª²¦Á and ILª²6 in different phases. RESULTS: The serum levels of PAF, TNFª²¦Á and ILª²6 of AP group significantly increased (P<0.01), and the serum level of TNFª²¦Á got to a peak at 6 h and the serum ILª²6 reached the highest level at 12 h after operation (P<0.01 vs control group). After TMP was used in AP rats, the serum levels of PAF, TNFª²¦Á and ILª²6 were signiª²ficantly decreased (P<0.05). CONCLUSION: TMP can inhibit inflammatory mediators and relieve the damages of the pancreas or lung in AP rats. ......