Role of VCAMª²1 in the vascular injury of pulmonary fibrosis

    CHEN Liª²Ping1, LIU Hua2, HE Yongª²Feng3, ZHU Xinª²Ju4, LI Lin1, LIU Xinª²She1

    1Department of Forensic Medicine, Medical College, Xi¬ðan Jiaotong University, Xi ¬ðan 710061, China, 2Beijing Public Security Bureau, Beijing 100085, China, 3Forensic Medical Identification Center, Shaanxi Public Security Bureau, Xi ¬ðan 710016, China, 4Zhenjiang Public Security Bureau, Zhenjiang 212000, China

    ¡¾Abstract¡¿ AIM: To explore the expression of vascular cell adhesion moleculeª²1(VCAMª²1) in pulmonary tissues of rats with bleomycin(BLM)ª²induced pulmonary fibrosis and the role of VCAMª²1 in vascular injury. METHODS: The immunoreaction of VCAMª²1 in pulmonary tissues of rats with BLMª²induced pulmonary fibrosis was analyzed by immunohistochemical technique and image processing system. RESULTS: The expression of VCAMª²1 in the lung tissues of normal rats was weak, and distributed mainly in alveolar epithelial cells, bronchiole epithelial cells, alveolar macrophage and some pulmonary interstitium. The expression of VCAMª²1 in lung tissues of rats with BLM ª²induced pulmonary fibrosis was higher than that in normal rats, with significant difference (P<0.05). CONCLUSION: VCAMª²1 is one of the important cell factors in BLMª²induced pulmonary fibrosis and it directly participates in the pulmonary inflammation and the process of fibrosis. ......