Efficacy enhancement and toxicity attenuation of Guiyuan oral solution in the treatment of transplanted tumors by CTX, DDP and 60Coª²¦Ã

    HE Jianª²Yu1, CAO Yongª²Xiao1, HUANG Linª²Hong1, TAO Xiaoª²Jun1, LIU Jing1, ZHANG Guiª²Jun2

    1Department of Pharmacology, Medical College, Xi¬ðan Jiaotong University, Xi¬ðan 710061, China, 2School of Chinese Pharmacy, Beijing University of Taditional Chinese Medicine, Beijing 100102, China

    ¡¾Abstract¡¿ AIM£º To investigate the efficacy enhancement and toxicity attenuation of Guiyuan oral solution in antitumor therapies. METHODS: The mice bearing transplanted tumors were treated by Guiyuan oral solution associated with chemotherapy or radiotherapy to study the effect of the oral solution by comparing the tumor weight, survival time, white blood cells, and nucleated cells in bone marrow between association therapy groups and simple chemotherapy or radiotherapy groups. RESULTS: The tumor weights of mice bearing sarcoma180 were obviously decreased in the groups of cyclophosphamide (CTX 5 mg/kg) associated with Guiyuan oral solution(10, 4, 1.6 g/kg) as compared with that in the CTX group. When both 60Coª² ¦Ã and Guiyuan oral solution(10, 4 g/kg) were administered to mice with sarcoma180, the tumor weights were decreased significantly, and tumor inhibition rates were 66.5% and 47.6 %, respectively, significantly higher than that in simple 60Coª²¦Ã group (23.6 %). When both cisplatin (DDP, 1 mg/kg) and Guiyuan oral solution (10 g/kg) were administered to mice with Ehrlich¡¯s ascites carcinoma, the survival time of the mice was prolonged significantly [(14.6¡À2.5) d vs (24.2¡À6.9) d], the rate of the prolonged survival time was raised from 30.1% to 65.3%. When Guiyuan oral solution (10, 4, 1.6 g/kg) associated with CTX (5 mg/kg) was administered to mice with leukemia L1210 ......