[摘要] 目的 探讨输血对危重患者医院内感染发生的影响。 方法 采用前瞻性随机对照试验方法。选择2004年1月～2006年11月我院ICU收治需输血治疗危重患者354例，其中普通悬浮红细胞输血组184例，悬浮去白细胞红细胞输血组共170例。对两组患者院内感染率及输血剂量与感染率的关系进行比较。 结果 普通悬浮红细胞输血组院内感染率为26.1%，悬浮去白细胞红细胞输血组院内感染率为9.4%，与普通悬浮红细胞输血组相比差异有非常显著性(χ2=16.59，P<0.01)。普通悬浮红细胞输血组的输血量与院内感染的发生显著相关(χ2=28.71，P<0.01)。结论 危重患者院内感染发生与输血、血液成分及输血量等有关。在保证患者循环稳定的情况下，应尽量减少输血，对确需输血的患者，应该输注去白细胞红细胞。

    [关键词] 输血；危重病；院内感染；去白细胞红细胞

    Effects of leukoreduced blood transfusion on nosocomial infection in critical patients:a prospective,randomized controlled trial

    LIU Ying-xun,YU Bang-xu，SONG Lei,et al.ICU Department, The Qingdao Chengyang Hospital,Qingdao 266109,China

    [Abstract] Objective To investigate the effect of leukoreduced blood transfusion on nosocomial infection rate in critical patients，and to guide reasonable blood transfusion. Methods Prospective,controlled study of transfusion practices in patients(n=354) admitted to the ICU from January 2004 to November 2006.randomized patients were transfused with packed red blood cell(pRBC)，170 with leukoreduced red blood cell (LDRC).The rates of nosocomial infection of two groups and the correlation to the amount of transfusion were compared. Results The rate of nosocomial infection of the pRBC group was 26.1%(48/184).The rate of nosocomial infection of the LDRC group was 9.4%(16/170) ......