混合性胆固醇结石体内灌注溶解实验
作者：章建东△ 李兆申 许国铭
单位：
关键词：混合性胆固醇结石；介入治疗；毒性
第四军医大学吉林军医学院学报000107摘 要：目的：探讨黄芩甙及其共沉淀物和固体分散物的生物利用度。方法：将黄芩甙、黄芩甙固体分散物和共沉淀物的混悬液，分别给3组家兔灌胃给药，不同时间经耳静脉取血，紫外分光光度仪测定血药浓度，计算药物动力学参数。结果：黄芩甙组、黄芩甙固体分散物组和黄芩甙共沉淀物组的平均吸收时间分别为(4.99±1.42)、(3.66±0.45)、(2.56±0.60)h，曲线下面积分别为(69.89±20.00)、(168.78±35.88)、(172.28±41.10)μg·h·ml-1，相对生物利用度分别为100.00%、241.49%、246.50%。结论：黄芩甙固体分散物和共沉淀物可显著提高黄芩甙的溶出速率，并明显增加黄芩甙的生物利用度。
Study on bioavailability of baicalin and its coprecipitats, solid dispersion
Li Dihui ,Jia Yuxi ,Huang Xiaojie
(Jilin Military Medical College, Jilin City, 132013)
Abstract：Objective: To study bioavnilability of baicalin and its coprecipitats, solid dispersion. Methods:With 3 groups of rabbits given the suspensions, plasma samples were collected from ear veins at different time and then plasma concentrations were determined by UV while pharmacokinetics parameters were also calculated. Results:The average absorption time in baicalin group, coprecipitat group and solid dispersion group were respectively(4.99±1.42), (3.66±0.45), (2.56±0.60)h, area under the curve (69.89±20.00), (163.78±35.88), (172.88±41.10)μg·h·ml-1, and relative bioavailability 100.00% ,241.49% ,246.50%. Conclusion: The coprecipitats and its solid dispersion can significantly increase dissolution rate of baiealin and obviously improve its bioavailability.
Keywords：baicalin; coprecipitat; solid dispersion; bioavailability
参考文献：
[1]毛凤斐，朱家壁，屠锡德等.黄芩甙的人体吸收研究.南京药学院学报，1983，14(1)：61
[2]颜耀东，张家象，黄晓洁等.黄芩甙共沉淀物和固体分散物的研究.中国药学杂志，1993，28(7)：411
[3]徐凯建，杨晓江，胡启茹等.双黄连静注、栓剂、微型灌肠剂的人体生物利用度研究.中成药研究，1987，2：1
收稿日期：1999-01-05, 百拇医药
单位：
关键词：混合性胆固醇结石；介入治疗；毒性
第四军医大学吉林军医学院学报000107摘 要：目的：探讨黄芩甙及其共沉淀物和固体分散物的生物利用度。方法：将黄芩甙、黄芩甙固体分散物和共沉淀物的混悬液，分别给3组家兔灌胃给药，不同时间经耳静脉取血，紫外分光光度仪测定血药浓度，计算药物动力学参数。结果：黄芩甙组、黄芩甙固体分散物组和黄芩甙共沉淀物组的平均吸收时间分别为(4.99±1.42)、(3.66±0.45)、(2.56±0.60)h，曲线下面积分别为(69.89±20.00)、(168.78±35.88)、(172.28±41.10)μg·h·ml-1，相对生物利用度分别为100.00%、241.49%、246.50%。结论：黄芩甙固体分散物和共沉淀物可显著提高黄芩甙的溶出速率，并明显增加黄芩甙的生物利用度。
Study on bioavailability of baicalin and its coprecipitats, solid dispersion
Li Dihui ,Jia Yuxi ,Huang Xiaojie
(Jilin Military Medical College, Jilin City, 132013)
Abstract：Objective: To study bioavnilability of baicalin and its coprecipitats, solid dispersion. Methods:With 3 groups of rabbits given the suspensions, plasma samples were collected from ear veins at different time and then plasma concentrations were determined by UV while pharmacokinetics parameters were also calculated. Results:The average absorption time in baicalin group, coprecipitat group and solid dispersion group were respectively(4.99±1.42), (3.66±0.45), (2.56±0.60)h, area under the curve (69.89±20.00), (163.78±35.88), (172.88±41.10)μg·h·ml-1, and relative bioavailability 100.00% ,241.49% ,246.50%. Conclusion: The coprecipitats and its solid dispersion can significantly increase dissolution rate of baiealin and obviously improve its bioavailability.
Keywords：baicalin; coprecipitat; solid dispersion; bioavailability
参考文献：
[1]毛凤斐，朱家壁，屠锡德等.黄芩甙的人体吸收研究.南京药学院学报，1983，14(1)：61
[2]颜耀东，张家象，黄晓洁等.黄芩甙共沉淀物和固体分散物的研究.中国药学杂志，1993，28(7)：411
[3]徐凯建，杨晓江，胡启茹等.双黄连静注、栓剂、微型灌肠剂的人体生物利用度研究.中成药研究，1987，2：1
收稿日期：1999-01-05, 百拇医药